| Evaluation of the bronchodilating and antiallergic properties of a beta-adrenoceptor stimulant, KWD 2131, in asthmatic patients. | |
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MedLine Citation:
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PMID: 6110383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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KWD 2131 (1-(3,5-dihydroxyphenyl)-(1,1dimethyl-2-hydroxyethyl-amino/ethanol sulphate) is a beta-adrenoceptor stimulating compound that has been shown to be equipotent to terbutaline with regard to inhibition of anaphylactic histamine release from guinea pig lung tissue but less potent than terbutaline as a cardioaccelerator in this species. In the present study KWD 2131 was found to be about 5-10 times less potent than terbutaline as a cardioaccelerator, tremorogenic and bronchodilator agent on subcutaneous (s.c.) injection in man. S.c. injection of KWD 2131 in a subthreshold dose for bronchodilation, i.e. 0.3 mg or 0.6 mg, given prior to a bronchial provocation test with specific allergen had no protective effect on the changes in specific airway conductance and peak expiratory flow in a double-blind cross-over study in 12 patients with allergic asthma. It is concluded that KWD 2131 probably has a less selective antiallergic activity in man as compared to guinea pig and that the methodology employed for the evaluation is useful for the characterization of antiallergic drugs with bronchodilator properties. |
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Authors:
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K O Pegelow; K Strandberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Allergy Volume: 35 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-04-21 Completed Date: 1981-04-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 509-19 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists* Adult Allergens Asthma / drug therapy*, etiology Bronchodilator Agents* Chronic Disease Clinical Trials as Topic Dose-Response Relationship, Drug Female Heart Rate / drug effects Histamine / pharmacology Humans Hypersensitivity / drug therapy* Male Peak Expiratory Flow Rate Random Allocation Terbutaline / analogs & derivatives*, therapeutic use Tremor / etiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Allergens; 0/Bronchodilator Agents; 23031-25-6/Terbutaline; 51-45-6/Histamine; 63546-99-6/KWD 2131 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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