Document Detail


Evaluation of the bronchodilating and antiallergic properties of a beta-adrenoceptor stimulant, KWD 2131, in asthmatic patients.
MedLine Citation:
PMID:  6110383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
KWD 2131 (1-(3,5-dihydroxyphenyl)-(1,1dimethyl-2-hydroxyethyl-amino/ethanol sulphate) is a beta-adrenoceptor stimulating compound that has been shown to be equipotent to terbutaline with regard to inhibition of anaphylactic histamine release from guinea pig lung tissue but less potent than terbutaline as a cardioaccelerator in this species. In the present study KWD 2131 was found to be about 5-10 times less potent than terbutaline as a cardioaccelerator, tremorogenic and bronchodilator agent on subcutaneous (s.c.) injection in man. S.c. injection of KWD 2131 in a subthreshold dose for bronchodilation, i.e. 0.3 mg or 0.6 mg, given prior to a bronchial provocation test with specific allergen had no protective effect on the changes in specific airway conductance and peak expiratory flow in a double-blind cross-over study in 12 patients with allergic asthma. It is concluded that KWD 2131 probably has a less selective antiallergic activity in man as compared to guinea pig and that the methodology employed for the evaluation is useful for the characterization of antiallergic drugs with bronchodilator properties.
Authors:
K O Pegelow; K Strandberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  35     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  509-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists*
Adult
Allergens
Asthma / drug therapy*,  etiology
Bronchodilator Agents*
Chronic Disease
Clinical Trials as Topic
Dose-Response Relationship, Drug
Female
Heart Rate / drug effects
Histamine / pharmacology
Humans
Hypersensitivity / drug therapy*
Male
Peak Expiratory Flow Rate
Random Allocation
Terbutaline / analogs & derivatives*,  therapeutic use
Tremor / etiology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Allergens; 0/Bronchodilator Agents; 23031-25-6/Terbutaline; 51-45-6/Histamine; 63546-99-6/KWD 2131

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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