Document Detail

Evaluation of bone mineral density of the lumbar spine in patients with beta-thalassemia major with dual-energy x-ray absorptiometry and quantitative computed tomography: a comparison study.
MedLine Citation:
PMID:  16462577     Owner:  NLM     Status:  MEDLINE    
Osteoporosis is a common, multifactorial cause of morbidity in patients with beta-thalassemia. The present study was performed to compare bone mineral density (BMD) results in the lumbar spine of thalassemic patients measured by both dual-energy x-ray absorptiometry (DEXA) and quantitative computed tomography (QCT), and to determine their correlations with the markers of bone turnover. BMD was measured in the lumbar spine of 13 regularly transfused patients with beta-thalassemia major by both DEXA and QCT. Blood and urine samples were obtained for the determination of biochemical and hormonal profiles. Both T-scores and Z-scores were higher when measured by QCT (T-score = -0.41 +/- 1.31, Z-score = -0.56 +/- 1.08, mean +/- SD) compared with the values given by DEXA (T-score = -2.57 +/- 0.88, Z-score = -2.32 +/- 1.11, P = 0.0005). In comparison to DEXA, QCT T-scores were more closely correlated with age (r = -0.19 vs. r = -0.70, P = 0.0068). Strong negative correlation was found between QCT values and age (r = -0.67, P = 0.01). In comparison to DEXA T-scores, QCT T-scores were more closely correlated with osteocalcin, urine N-telopeptide cross-links of type I collagen, and deoxypyridinoline, but without statistical significance. DEXA T-scores were better correlated only with urine C-terminal telopeptides of type I collagen, but again without statistical significance. These results imply that the two methods cannot be used interchangeably in assessing BMD in thalassemic patients. However, which one of these two techniques more precisely determines the overall strength of vertebrae in patients with beta-thalassemia remains to be investigated.
Nicholas G Angelopoulos; Eugenia Katounda; Grigorios Rombopoulos; Anastasia Goula; Victoria Kaltzidou; Dimitrios Kaltsas; Pappas Ioannis; George Tolis
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  28     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-31     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Endocrine Department, Hippokrateion Hospital of Athens, Athens, Greece.
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MeSH Terms
Absorptiometry, Photon*
Alkaline Phosphatase / blood
Amino Acids / urine
Biological Markers
Blood Transfusion / adverse effects
Bone Density*
Collagen / urine
Collagen Type I
Lumbar Vertebrae / radiography*
Osteocalcin / blood
Osteoporosis / blood,  etiology*,  radiography,  urine
Peptides / urine
Predictive Value of Tests
Tomography, X-Ray Computed / methods*
beta-Thalassemia / complications*,  metabolism,  physiopathology,  therapy
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 0/Collagen Type I; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 104982-03-8/Osteocalcin; 90032-33-0/deoxypyridinoline; 9007-34-5/Collagen; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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