Document Detail

Evaluation of body composition and cartilage biomarkers in large-breed dogs fed two foods designed for growth.
MedLine Citation:
PMID:  20673093     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate cartilage and bone biomarkers and body composition in growing large-breed dogs consuming a diet designed for growth.
ANIMALS: 43 large-breed 2 month-old-puppies.
PROCEDURES: Dogs were randomly assigned to receive 1 of 2 foods until 18 months of age. Dogs were evaluated at 2, 5, 12, and 18 months of age via dual energy x-ray absorptiometry (DEXA), CBC, serum biochemical profile, and concentrations or activities of taurine, vitamin E, fatty acids, glutathione peroxidase, C-propeptide of type II collagen (CPII), cartilage oligomeric matrix protein (COMP), carboxy-terminal cross-linked fragment of type II collagen (CTXII), bone specific alkaline phosphatase (BAP), osteocalcin, ghrelin, and growth hormone.
RESULTS: Blood components largely reflected the composition of the foods. Dogs fed the food with a higher concentration of protein, calcium, n-3 fatty acids, and antioxidants had a lower percentage of body fat and greater percentage of lean body mass at 5, 12, and 18 months of age, and higher CPII:CTXII ratio and lower COMP at 18 months of age. The BAP activity, osteocalcin concentration, and CTXII concentration declined with age, whereas COMP concentration and CPII concentration were similar at all time points for both foods.
CONCLUSIONS AND CLINICAL RELEVANCE: The BAP activity, osteocalcin concentration, and CTXII concentration were greater during growth than at 18 months of age. The food that was proportionately higher in protein, calcium, n-3 fatty acids, and antioxidants increased lean body mass and may have positively affected cartilage turnover as maturity was attained. Whether the rate of cartilage turnover during growth affects development of orthopedic disease or arthritis in adulthood has yet to be determined.
William D Schoenherr; Jennifer M Macleay; Ryan M Yamka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  71     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-09-21     Revised Date:  2010-11-23    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  934-9     Citation Subset:  IM    
Hill's Pet Nutrition Incorporated, Pet Nutrition Center, Topeka, KS 66601, USA.
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MeSH Terms
Absorptiometry, Photon
Alkaline Phosphatase / blood,  metabolism
Animal Feed*
Biological Markers / blood
Blood Chemical Analysis / methods,  veterinary
Body Composition*
Body Size
Bone Development
Bone and Bones / metabolism
Cartilage / growth & development,  physiology*
Dogs / anatomy & histology*
Ghrelin / blood
Glutathione Peroxidase / blood
Growth Hormone / blood
Osteocalcin / blood,  metabolism
Taurine / blood
Reg. No./Substance:
0/Biological Markers; 0/Ghrelin; 104982-03-8/Osteocalcin; 107-35-7/Taurine; 9002-72-6/Growth Hormone; EC Peroxidase; EC Phosphatase
Erratum In:
Am J Vet Res. 2010 Oct;71(10):1206

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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