Document Detail

Evaluation of baseline structural factors for predicting glaucomatous visual-field progression using optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy.
MedLine Citation:
PMID:  23060026     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this study is to assess whether baseline optic nerve head (ONH) topography and retinal nerve fiber layer thickness (RNFLT) are predictive of glaucomatous visual-field progression in glaucoma suspect (GS) and glaucomatous eyes, and to calculate the level of risk associated with each of these parameters.
METHODS: Participants with ≥28 months of follow-up were recruited from the longitudinal Advanced Imaging for Glaucoma Study. All eyes underwent standard automated perimetry (SAP), confocal scanning laser ophthalmoscopy (CSLO), time-domain optical coherence tomography (TDOCT), and scanning laser polarimetry using enhanced corneal compensation (SLPECC) every 6 months. Visual-field progression was assessed using pointwise linear-regression analysis of SAP sensitivity values (progressor) and defined as significant sensitivity loss of >1 dB/year at ≥2 adjacent test locations in the same hemifield at P<0.01. Cox proportional hazard ratios (HR) were calculated to determine the predictive ability of baseline ONH and RNFL parameters for SAP progression using univariate and multivariate models.
RESULTS: Seventy-three eyes of 73 patients (43 GS and 30 glaucoma, mean age 63.2±9.5 years) were enrolled (mean follow-up 51.5±11.3 months). Four of 43 GS (9.3%) and 6 of 30 (20%) glaucomatous eyes demonstrated progression. Mean time to progression was 50.8±11.4 months. Using multivariate models, abnormal CSLO temporal-inferior Moorfields classification (HR=3.76, 95% confidence interval (CI): 1.02-6.80, P=0.04), SLPECC inferior RNFLT (per -1 μm, HR=1.38, 95% CI: 1.02-2.2, P=0.02), and TDOCT inferior RNFLT (per -1 μm, HR=1.11, 95% CI: 1.04-1.2, P=0.001) had significant HRs for SAP progression.
CONCLUSION: Abnormal baseline ONH topography and reduced inferior RNFL are predictive of SAP progression in GS and glaucomatous eyes.
M Sehi; N Bhardwaj; Y S Chung; D S Greenfield;
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-12
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-05-07     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1527-35     Citation Subset:  IM    
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MeSH Terms
Disease Progression
Follow-Up Studies
Glaucoma / diagnosis,  physiopathology*
Intraocular Pressure
Lasers / diagnostic use*
Middle Aged
Ophthalmoscopy / methods*
Optic Nerve / pathology
Prospective Studies
Reproducibility of Results
Scanning Laser Polarimetry / methods*
Tomography, Optical Coherence / methods*
Visual Field Tests / methods*
Visual Fields*
Grant Support
P30EY014801/EY/NEI NIH HHS; R01 EY013516/EY/NEI NIH HHS; R01-EY013516/EY/NEI NIH HHS
D S Greenfield / ; M Sehi / ; C D Quinn / ; K Kishor / ; J S Schuman / ; G Wollstein / ; H Ishikawa / ; R J Noecker / ; Larry Kagemann / ; R Varma / ; V Chopra / ; B Francis / ; D Huang / ; J Morrison / ; P Francis / ; B Edmunds / ; M Parikh / ; D Gatty / ; R Armour / ; L Lombardi / ; O Tan / ; Xinbo Zhang / ; Yimin Wang /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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