Document Detail

Evaluation of balhimycin as a chiral selector for enantioresolution by capillary electrophoresis.
MedLine Citation:
PMID:  15351999     Owner:  NLM     Status:  MEDLINE    
The glycopeptide antibiotic balhimycin and its haloanalogue bromobalhimycin were evaluated as chiral selectors for enantioresolution by capillary electrophoresis. In order (i) to eliminate the adsorption of the glycopeptide antibiotics on the capillary wall, (ii) to shorten the separation time and (iii) to improve the detection sensitivity, a combined approach of the dynamic surface coating technique, the co-electroosmotic flow electrophoresis technique and the partial filling technique was employed for the enantioresolution of 16 acidic racemates. The effect of experimental parameters (plug length of the partial filling solution containing the chiral selector, selector concentration and buffer pH) on enantiorecognition was investigated. Furthermore, the enantiorecognition ability imparted by balhimycin, bromobalhimycin and vancomycin were compared. For most tested compounds, the highest enantiorecognition was obtained with balhimycin as chiral selector. Only in the case of the enantioresolution of tiaprofenic acid, vancomycin showed a superior enantiorecognition.
Zhengjin Jiang; Jingwu Kang; Daniel Bischoff; Bojan Bister; Roderich D Süssmuth; Volker Schurig
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Electrophoresis     Volume:  25     ISSN:  0173-0835     ISO Abbreviation:  Electrophoresis     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2005-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2687-92     Citation Subset:  IM    
Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  isolation & purification*
Electrophoresis, Capillary / methods*
Hydrogen-Ion Concentration
Molecular Structure
Vancomycin / analogs & derivatives*,  chemistry*,  isolation & purification*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Buffers; 1404-90-6/Vancomycin; 140932-79-2/balhimycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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