| Evaluation of balhimycin as a chiral selector for enantioresolution by capillary electrophoresis. | |
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MedLine Citation:
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PMID: 15351999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The glycopeptide antibiotic balhimycin and its haloanalogue bromobalhimycin were evaluated as chiral selectors for enantioresolution by capillary electrophoresis. In order (i) to eliminate the adsorption of the glycopeptide antibiotics on the capillary wall, (ii) to shorten the separation time and (iii) to improve the detection sensitivity, a combined approach of the dynamic surface coating technique, the co-electroosmotic flow electrophoresis technique and the partial filling technique was employed for the enantioresolution of 16 acidic racemates. The effect of experimental parameters (plug length of the partial filling solution containing the chiral selector, selector concentration and buffer pH) on enantiorecognition was investigated. Furthermore, the enantiorecognition ability imparted by balhimycin, bromobalhimycin and vancomycin were compared. For most tested compounds, the highest enantiorecognition was obtained with balhimycin as chiral selector. Only in the case of the enantioresolution of tiaprofenic acid, vancomycin showed a superior enantiorecognition. |
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Authors:
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Zhengjin Jiang; Jingwu Kang; Daniel Bischoff; Bojan Bister; Roderich D Süssmuth; Volker Schurig |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Electrophoresis Volume: 25 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2005-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 2687-92 Citation Subset: IM |
Affiliation:
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Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry*,
isolation & purification* Buffers Electrophoresis, Capillary / methods* Hydrogen-Ion Concentration Molecular Structure Stereoisomerism Vancomycin / analogs & derivatives*, chemistry*, isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Buffers; 1404-90-6/Vancomycin; 140932-79-2/balhimycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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