Document Detail

Evaluation of awakening and recovery characteristics following anaesthesia with nitrous oxide and halothane fentanyl or both for brief outpatient procedures in infants.
MedLine Citation:
PMID:  9308063     Owner:  NLM     Status:  MEDLINE    
This study compared recovery characteristics and postoperative ventilatory function when halothane, fentanyl or combination of halothane and fentanyl in addition to N2O were used for intraoperative anaesthesia in term infants undergoing hernia repair as outpatients. Sixty-six full term ASA PS I infants ages 1-12 months were studied. All received inhalation induction with N2O, O2 and halothane, followed by intravenous atropine and atracurium, tracheal intubation, and controlled ventilation. For anaesthesia maintenance, patients were randomized into one of three groups. Group I received 70% N2O, 30% O2 and halothane. Group II received 70% N2O, 30% O2, halothane and 2 fentanyl. Group III received 70% N2O, 30% O2 and 10 fentanyl. Awakening times were similar in all three groups, however, Group I patients had significantly shorter recovery and discharge times than those of Group II and III. None of the patients experienced postoperative apnoea or periodic breathing. One patient in Group III experienced two brief episodes of bradycardia not associated with apnoea or arterial desaturation (SpO2 > 90% for greater than 30 s). Decreased SpO2 occurred less frequently in Group I (5.9%) compared to Group II (22.7%) and Group III (19.0%) patients, however, the group differences were not significant. Transcutaneous CO2 (TcCO2) values were not statistically different among the three groups. Pain scores were initially lower in Groups II and III, but at 120 min the differences were not significant. Postoperative apnoea was not observed in this study. SpO2 < 90% and TcCO2 > 9 kPa (70 mmHg) was more common in infants receiving 2 and 10 fentanyl than in infants receiving halothane and nitrous oxide anaesthesia. Infants < 3 months old did not have a higher incidence of SpO2 < 90% or significantly higher TcCO2 values when compared to infants > 3 months old. Fentanyl in doses used in this study did not prolong awakening time but did prolong recovery and discharge times in outpatient infants.
K J Roetman; L G Welborn; R S Hannallah; R Fink; J M Norden; R O'Donnell
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  7     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-30     Completed Date:  1997-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Department of Anesthesiology, Children's National Medical Center, Washington, DC, USA.
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MeSH Terms
Ambulatory Surgical Procedures
Anesthesia Recovery Period*
Anesthetics, Combined*
Anesthetics, Inhalation* / adverse effects
Anesthetics, Intravenous* / adverse effects
Carbon Dioxide / blood
Fentanyl* / adverse effects
Halothane* / adverse effects
Nitrous Oxide* / adverse effects
Oxygen / blood
Pain, Postoperative / drug therapy
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 437-38-7/Fentanyl; 7782-44-7/Oxygen

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