| Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques. | |
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MedLine Citation:
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PMID: 17560585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comparison was made between electrospray, atmospheric pressure chemical and atmospheric pressure photospray ionizations to evaluate the MS/MS responses of standard sulfonamides and honey spiked samples. The sample preparation entails an acidic hydrolysis followed by a liquid/liquid extraction. Full method validation was realised by LC-APPI-MS/MS. Decision limit and detection capability were calculated for each analyte (at 50 microg/kg) and ranged between 53.6 and 56.9 and 57.5 and 63.2 microg/kg, respectively. Limits of detection and of quantification ranged, respectively, at 0.4-4.5 and 1.2-15.0 microg/kg. Precursor ion scan experiments of m/z 92 were also carried out as a survey experiment, linked with an enhanced product ion scan experiment to potentially identified additional sulfonamides via a library search. |
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Authors:
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Rayane Mohamed; Yves-Alexis Hammel; Marie-Hélène LeBreton; Jean-Claude Tabet; Laure Jullien; Philippe A Guy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-29 |
Journal Detail:
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Title: Journal of chromatography. A Volume: 1160 ISSN: 0021-9673 ISO Abbreviation: J Chromatogr A Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-30 Completed Date: 2007-09-27 Revised Date: 2009-01-15 |
Medline Journal Info:
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Nlm Unique ID: 9318488 Medline TA: J Chromatogr A Country: Netherlands |
Other Details:
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Languages: eng Pagination: 194-205 Citation Subset: IM |
Affiliation:
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Nestlé Research Center, Nestec Ltd., P.O. Box 44, Vers-chez-les Blanc, 1000 Lausanne 26, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Atmospheric Pressure* Calibration Chromatography, Liquid Honey / analysis* Indicator Dilution Techniques* Reproducibility of Results Spectrometry, Mass, Electrospray Ionization Sulfonamides / analysis*, chemistry Tandem Mass Spectrometry / methods* |
| Chemical | |
Reg. No./Substance:
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0/Sulfonamides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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