Document Detail

Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques.
MedLine Citation:
PMID:  17560585     Owner:  NLM     Status:  MEDLINE    
A comparison was made between electrospray, atmospheric pressure chemical and atmospheric pressure photospray ionizations to evaluate the MS/MS responses of standard sulfonamides and honey spiked samples. The sample preparation entails an acidic hydrolysis followed by a liquid/liquid extraction. Full method validation was realised by LC-APPI-MS/MS. Decision limit and detection capability were calculated for each analyte (at 50 microg/kg) and ranged between 53.6 and 56.9 and 57.5 and 63.2 microg/kg, respectively. Limits of detection and of quantification ranged, respectively, at 0.4-4.5 and 1.2-15.0 microg/kg. Precursor ion scan experiments of m/z 92 were also carried out as a survey experiment, linked with an enhanced product ion scan experiment to potentially identified additional sulfonamides via a library search.
Rayane Mohamed; Yves-Alexis Hammel; Marie-Hélène LeBreton; Jean-Claude Tabet; Laure Jullien; Philippe A Guy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-29
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1160     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-27     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  194-205     Citation Subset:  IM    
Nestlé Research Center, Nestec Ltd., P.O. Box 44, Vers-chez-les Blanc, 1000 Lausanne 26, Switzerland.
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MeSH Terms
Atmospheric Pressure*
Chromatography, Liquid
Honey / analysis*
Indicator Dilution Techniques*
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization
Sulfonamides / analysis*,  chemistry
Tandem Mass Spectrometry / methods*
Reg. No./Substance:

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