Document Detail


Evaluation of atmospheric pressure ionization interfaces for quantitative measurement of sulfonamides in honey using isotope dilution liquid chromatography coupled with tandem mass spectrometry techniques.
MedLine Citation:
PMID:  17560585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison was made between electrospray, atmospheric pressure chemical and atmospheric pressure photospray ionizations to evaluate the MS/MS responses of standard sulfonamides and honey spiked samples. The sample preparation entails an acidic hydrolysis followed by a liquid/liquid extraction. Full method validation was realised by LC-APPI-MS/MS. Decision limit and detection capability were calculated for each analyte (at 50 microg/kg) and ranged between 53.6 and 56.9 and 57.5 and 63.2 microg/kg, respectively. Limits of detection and of quantification ranged, respectively, at 0.4-4.5 and 1.2-15.0 microg/kg. Precursor ion scan experiments of m/z 92 were also carried out as a survey experiment, linked with an enhanced product ion scan experiment to potentially identified additional sulfonamides via a library search.
Authors:
Rayane Mohamed; Yves-Alexis Hammel; Marie-Hélène LeBreton; Jean-Claude Tabet; Laure Jullien; Philippe A Guy
Related Documents :
16583695 - Determination of beef tallow in lard through a multidimensional off-line non-aqueous re...
12590385 - Determination of perfluorooctane sulfonate in river water by liquid chromatography/atmo...
6775945 - Applications of a versatile technique for trace analysis: atmospheric pressure negative...
22088355 - Selection of the derivatization reagent-the case of human blood cholesterol, its precur...
16113995 - Enantioselective binding to the human organic cation transporter-1 (hoct1) determined u...
22154075 - Development and validation of a bioanalytical lc-ms method for the quantification of gh...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-29
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1160     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-27     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  194-205     Citation Subset:  IM    
Affiliation:
Nestlé Research Center, Nestec Ltd., P.O. Box 44, Vers-chez-les Blanc, 1000 Lausanne 26, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Atmospheric Pressure*
Calibration
Chromatography, Liquid
Honey / analysis*
Indicator Dilution Techniques*
Reproducibility of Results
Spectrometry, Mass, Electrospray Ionization
Sulfonamides / analysis*,  chemistry
Tandem Mass Spectrometry / methods*
Chemical
Reg. No./Substance:
0/Sulfonamides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A new algorithm of piecewise automated beam search for peak alignment of chromatographic fingerprint...
Next Document:  Estimation of recovery by multistep purge-and-trap gas chromatographic-mass spectrometric analysis o...