| Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome. | |
| | |
MedLine Citation:
|
PMID: 20695761 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective. To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters. Methods. Twenty-two obese, 18 lean patients with PCOS and 11 obese, 24 lean healthy control patients were enrolled prospectively. Plasma ADMA and NO levels and arginine/ADMA ratio were evaluated on 3rd day of menstrual cycle after at least 10 h overnight fasting. Results. Plasma ADMA, NO levels and arginine/ADMA ratio were similar in the groups. ADMA level did not correlate with the hormonal and metabolic parameters in patients with PCOS. However, NO correlated inversely with fasting insulin (r = -0.353, p = 0.041) and homeostasis model of insulin resistance (HOMA-IR) (r = -0.379, p = 0.027). Arginine/ADMA ratio also correlated inversely with fasting insulin (r = -0.339, p = 0.050). In multinomial regression analysis the risk of low NO was associated independently with high fasting insulin (OR = 1.19, 95% CI 1.001-1.42, p = 0.049) and high HOMA-IR in patients with PCOS (OR = 2.26, 95% CI 1.03-4.98, p = 0.042). Conclusions. Insulin resistance may be the underlying mechanism of endothelial dysfunction through NO pathway in PCOS. |
| | |
Authors:
|
Ilgin Türkçüoğlu; Yaprak Engin-Üstün; Fahri Turan; Zercan Kali; Aysun Bay Karabulut; Mutlu Meydanli; Ayşe Kafkasli |
Publication Detail:
|
Type: Journal Article Date: 2010-08-09 |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 27 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 609-14 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, İnönü University School of Medicine, Malatya, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Uterine contractility is strongly influenced by steroids and glucose metabolism: an in vitro study o...
Next Document: Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processing.