| Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia. | |
| | |
MedLine Citation:
|
PMID: 17171665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The association of the tumor necrosis factor alpha (TNFalpha) -G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFalpha cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFalpha gene is located as well as association with the -G308A promoter polymorphism. While the common G-allele shows association in our sample, association with the A-allele has been reported by other groups. This suggests linkage disequilibrium (LD) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165-kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the -G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (79 sib-pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. |
| | |
Authors:
|
B Morar; S G Schwab; M Albus; W Maier; B Lerer; D B Wildenauer |
Related Documents
:
|
20507645 - Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene he... 19188535 - Association of variants in disc1 with psychosis-related traits in a large population co... 3360025 - Familial syndrome patterns in schizophrenia, schizoaffective disorder, mania, and depre... 16402085 - Apolipoprotein d is associated with long-term outcome in patients with schizophrenia. 22347485 - The drosophila trpp cation channel, pkd2 and dmel/ced-12 act in genetically distinct pa... 11350255 - An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synt... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Volume: 144B ISSN: 1552-4841 ISO Abbreviation: Am. J. Med. Genet. B Neuropsychiatr. Genet. Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-02 Completed Date: 2007-07-18 Revised Date: 2008-05-21 |
Medline Journal Info:
|
Nlm Unique ID: 101235742 Medline TA: Am J Med Genet B Neuropsychiatr Genet Country: United States |
Other Details:
|
Languages: eng Pagination: 318-24 Citation Subset: IM |
Copyright Information:
|
(c) 2006 Wiley-Liss, Inc. |
Affiliation:
|
CCRN/WAIMR Neuropsychiatric Genetics Laboratory, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia. bmorar@cyllene.uwa.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Family Gene Frequency Genes, MHC Class I Genetic Markers Haplotypes Humans Linkage Disequilibrium* Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide* Schizophrenia / genetics* Tumor Necrosis Factor-alpha / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families.
Next Document: Early evolution and biogeography of lorisiform strepsirrhines.