Document Detail

Evaluation of the antiseptic efficacy and local tolerability of a polihexanide-based antiseptic on resident skin flora.
MedLine Citation:
PMID:  22914036     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : The primary objective of this study was to compare the antimicrobial efficacy of polihexanide 0.02% and 0.04% with chlorhexidine 0.05% after 30 minutes of topical treatment on healthy intact skin.
DESIGN: : This study was performed as a double-blind, randomized, comparator-controlled, 3-arm, crossover study.
SETTING: : A phase I dermatological study unit.
PARTICIPANTS: : Twenty healthy volunteers with intact skin.
INTERVENTIONS: : Test areas of 5 cm on the subjects' arms were treated with the investigational products using a polyurethane swab. Skin swabs were taken before and after treatment for quantitative microbial evaluation.
MAIN OUTCOME MEASURES: : The main outcome measure was the log reduction factor of colony-forming units on the skin after 30 minutes of treatment.
MAIN RESULTS: : No statistically significant difference was seen between both of the polihexanide test products (mean lgRF polihexanide 0.02%, 1.2251 [SD, 0.9399]; mean lgRF polihexanide 0.04%, 1.8991 [SD, 0.88]) and the comparator, chlorhexidine 0.05% (P > .1).
CONCLUSION: : The results of this study indicate that polihexanide is a suitable alternative to chlorhexidine for skin and wound antisepsis.
Dianne Egli-Gany; Florian H H Brill; Matthias Hintzpeter; Simone Andrée; Viktoria Pavel
Related Documents :
24830166 - Evaluation of the thermo scientific suretect salmonella species assay. aoac performance...
24243256 - The use of phytotoxicity tests (common duckweed, cabbage, and millet) for determining e...
24140966 - Genotoxic evaluation of aspirin eugenol ester using the ames test and the mouse bone ma...
23280766 - Comparing the effectiveness of chronic water column tests with the crustaceans hyalella...
17935916 - A mini review of scientific and pharmacopeial requirements for the disintegration test.
21324446 - At home testing: optimizing management for the infertility physician.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  25     ISSN:  1538-8654     ISO Abbreviation:  Adv Skin Wound Care     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  N    
Dianne Egli-Gany, MSc, is Medical Affairs Manager, B. Braun Medical Ltd, Sempach, Switzerland. Florian H.H. Brill, PhD, is Managing Director, Dr Brill + Partner GmbH, Hamburg, Germany. Matthias Hintzpeter, PhD, is Manager, Regulatory Affairs, B. Braun Melsungen AG, Melsungen, Germany. Simone Andrée, MSc, is Medical Writer, and Viktoria Pavel, PhD, is Project Manager, Proinnovera GmbH, Munster, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of a Keratin-Based Wound Dressing in the Management of Wounds in a Patient with Recessive Dystro...
Next Document:  Prospective cohort study on surgical wounds comparing a polyhexanide-containing biocellulose dressin...