Document Detail


Evaluation of the antiseptic efficacy and local tolerability of a polihexanide-based antiseptic on resident skin flora.
MedLine Citation:
PMID:  22914036     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: : The primary objective of this study was to compare the antimicrobial efficacy of polihexanide 0.02% and 0.04% with chlorhexidine 0.05% after 30 minutes of topical treatment on healthy intact skin.
DESIGN: : This study was performed as a double-blind, randomized, comparator-controlled, 3-arm, crossover study.
SETTING: : A phase I dermatological study unit.
PARTICIPANTS: : Twenty healthy volunteers with intact skin.
INTERVENTIONS: : Test areas of 5 cm on the subjects' arms were treated with the investigational products using a polyurethane swab. Skin swabs were taken before and after treatment for quantitative microbial evaluation.
MAIN OUTCOME MEASURES: : The main outcome measure was the log reduction factor of colony-forming units on the skin after 30 minutes of treatment.
MAIN RESULTS: : No statistically significant difference was seen between both of the polihexanide test products (mean lgRF polihexanide 0.02%, 1.2251 [SD, 0.9399]; mean lgRF polihexanide 0.04%, 1.8991 [SD, 0.88]) and the comparator, chlorhexidine 0.05% (P > .1).
CONCLUSION: : The results of this study indicate that polihexanide is a suitable alternative to chlorhexidine for skin and wound antisepsis.
Authors:
Dianne Egli-Gany; Florian H H Brill; Matthias Hintzpeter; Simone Andrée; Viktoria Pavel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  25     ISSN:  1538-8654     ISO Abbreviation:  Adv Skin Wound Care     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  N    
Affiliation:
Dianne Egli-Gany, MSc, is Medical Affairs Manager, B. Braun Medical Ltd, Sempach, Switzerland. Florian H.H. Brill, PhD, is Managing Director, Dr Brill + Partner GmbH, Hamburg, Germany. Matthias Hintzpeter, PhD, is Manager, Regulatory Affairs, B. Braun Melsungen AG, Melsungen, Germany. Simone Andrée, MSc, is Medical Writer, and Viktoria Pavel, PhD, is Project Manager, Proinnovera GmbH, Munster, Germany.
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