Document Detail

Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial.
MedLine Citation:
PMID:  23318104     Owner:  NLM     Status:  Publisher    
Objective: There are many well-known aetiological mechanisms of presbyacusis, and free radicals have been shown to play an important role. This study aimed to evaluate the effect of antioxidant agents on the hearing threshold of patients with presbyacusis. Methods: One hundred and twenty individuals were divided into four groups and received one of the following treatment schemes: ginkgo biloba dry extract, α-lipoic acid plus vitamin C, papaverine chlorhydrate plus vitamin E, or placebo. All participants were evaluated at recruitment and after six months, using pure tone audiometry (at isolated and average frequencies), speech recognition threshold and percentage index of speech recognition. Results: The various treatments had no effect on any of the evaluated measures of hearing, either between groups or over time. Conclusion: There was no statistically significant change in the hearing threshold after treatment with any of the tested drugs, during the study period.
J F Polanski; O L Cruz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  -     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-8     Citation Subset:  -    
Division of Otology and Neurotology, Department of Otolaryngology and Head and Neck Surgery, Federal University of São Paulo, Brazil.
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