| Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial. | |
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MedLine Citation:
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PMID: 23318104 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: There are many well-known aetiological mechanisms of presbyacusis, and free radicals have been shown to play an important role. This study aimed to evaluate the effect of antioxidant agents on the hearing threshold of patients with presbyacusis. Methods: One hundred and twenty individuals were divided into four groups and received one of the following treatment schemes: ginkgo biloba dry extract, α-lipoic acid plus vitamin C, papaverine chlorhydrate plus vitamin E, or placebo. All participants were evaluated at recruitment and after six months, using pure tone audiometry (at isolated and average frequencies), speech recognition threshold and percentage index of speech recognition. Results: The various treatments had no effect on any of the evaluated measures of hearing, either between groups or over time. Conclusion: There was no statistically significant change in the hearing threshold after treatment with any of the tested drugs, during the study period. |
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Authors:
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J F Polanski; O L Cruz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
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Title: The Journal of laryngology and otology Volume: - ISSN: 1748-5460 ISO Abbreviation: J Laryngol Otol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: - |
Other Details:
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Languages: ENG Pagination: 1-8 Citation Subset: - |
Affiliation:
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Division of Otology and Neurotology, Department of Otolaryngology and Head and Neck Surgery, Federal University of São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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