| Evaluation of antioxidant status in liver tissues: effect of iron supplementation in experimental hyperthyroidism. | |
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MedLine Citation:
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PMID: 10631595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antioxidant defense system in liver tissue in experimental hyperthyroidism and/or in iron supplementation was investigated. Thyroid hormones (T3, T4, TSH), ferritin (marker of iron status), antioxidant status components (glutathione [GSH], glutathione peroxidase [GSH-Px], superoxide dismutase [SOD]), and serum transaminases (GOT and GPT, both of which are known to be released from damaged hepatocytes), were measured. Hyperthyroidism in rats, induced by L-thyroxine administration, significantly raised SOD activity (p < 0.05), but significantly decreased GSH-Px activity and GSH values (p < 0.001) in the liver. In the L-thyroxine administered and iron supplemented (TI) group, GSH and GSH-Px values of liver tissues were significantly lower than those of control rats (p < 0.05). GSH-Px levels of the TI group were higher (p < 0.001), and SOD levels significantly lower (p < 0.001) than those of the L-thyroxine administered group. We conclude that hyperthyroidism induces SOD activity in liver; ferritin levels increase in hyperthyroidism, contributing to the antioxidant defense system; GSH-Px and GSH levels are decreased significantly in hyperthyroidism either due to inactivation due to increased oxidative stress or to insufficient synthesis; iron supple- and GPT analysis); iron decreases the effect of T4. This must be taken into consideration during iron supplementation. |
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Authors:
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H O Seymen; A Seven; S Civelek; G Yiğit; H Hatemi; G Burçak |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of basic and clinical physiology and pharmacology Volume: 10 ISSN: 0792-6855 ISO Abbreviation: J Basic Clin Physiol Pharmacol Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101750 Medline TA: J Basic Clin Physiol Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 315-25 Citation Subset: IM |
Affiliation:
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Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University, Turkey. seymano@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Supplements Ferritins / blood Glutathione / analysis Glutathione Transferase / analysis Hyperthyroidism / metabolism* Iron / pharmacology* Liver / enzymology, metabolism* Male Rats Rats, Wistar Superoxide Dismutase / analysis Thyroid Hormones / blood Thyroxine / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones; 70-18-8/Glutathione; 7439-89-6/Iron; 7488-70-2/Thyroxine; 9007-73-2/Ferritins; EC 1.15.1.1/Superoxide Dismutase; EC 2.5.1.18/Glutathione Transferase |
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