Document Detail


Evaluation of antimuscarinic activity in human volunteers: a teaching aid in clinical pharmacology.
MedLine Citation:
PMID:  7649608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antimuscarinic activity of oxyphenonium bromide, diphenhydramine hydrochloride and astemizole were evaluated in six volunteers. The parameters used were salivary secretion, heart rate and pupillary size. The results indicated that the changes in heart rate and pupillary size and measurements were not convenient parameters for class room demonstration. However, salivary secretion and dryness of mouth were found to be reliable parameters for measurement. It was concluded that simple procedures like evaluation of antimuscarinic activity could be introduced as teaching aids in clinical pharmacology for undergraduate students.
Authors:
S K Tripathi; C R Griyappanavar; A Lal; K Biswas; N R Biswas; A Sankaranarayanan; P L Sharma
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  39     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-26     Completed Date:  1995-09-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  163-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.
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MeSH Terms
Descriptor/Qualifier:
Adult
Astemizole / administration & dosage,  pharmacology*
Diphenhydramine / administration & dosage,  pharmacology*
Education, Medical / standards
Heart Rate / drug effects
Humans
Male
Muscarinic Antagonists*
Oxyphenonium / administration & dosage,  pharmacology*
Pupil / drug effects
Salivation / drug effects
Students, Medical
Chemical
Reg. No./Substance:
0/Muscarinic Antagonists; 14214-84-7/Oxyphenonium; 58-73-1/Diphenhydramine; 68844-77-9/Astemizole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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