Document Detail


Evaluation of the antihypertensive effect of TTS clonidine by multiple 24-hour automatic blood pressure monitoring.
MedLine Citation:
PMID:  2455177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transdermal clonidine (TTSC) has been proposed as a means to improve compliance to treatment of hypertensive patients because of the reported 7-day duration of its antihypertensive effect. However, no detailed information is available on the onset, the time course, and the day and night distribution of this effect throughout the 7 days of the drug skin application. In 12 hospital in-patients with mild or moderate untreated essential hypertension, 24-h blood pressure (BP) was measured at 10-20 min intervals via a noninvasive automatic device (Spacelabs 5300 M) in a no-drug condition, on the 2nd, 4th, and 7th day of the arm application of a 7.0 or 10.5 cm2 patch of TTS clonidine, and on the 2nd and 4th day after substitution of the TTS clonidine patch with an identical patch containing an inert substance (placebo). In nine out of 12 patients, TTS clonidine reduced 24-h systolic and diastolic blood pressure at the 2nd day and even more so on the 4th and 7th day of its application. The reduced blood pressure values observed on the 7th day increased progressively on the 2nd and 4th day after TTS clonidine removal with no rebound over the pre-drug values. The hypotensive effects observed during TTS clonidine were evident throughout the day and night. Thus TTS clonidine exerts a hypotensive effect that starts early and is maintained throughout the 7 days and nights of its application. The discontinuation of this treatment is associated with a smooth return of blood pressure values towards the pre-treatment levels.
Authors:
G Mancia; G Parati; G Pomidossi; D Malaspina; A Colombo; C Camesasca; A Groppelli; R Casadei; A Zanchetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S187-93     Citation Subset:  IM    
Affiliation:
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Blood Pressure
Clonidine / administration & dosage*
Computers
Female
Heart Rate
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Monitoring, Physiologic
Skin Absorption
Time Factors
Chemical
Reg. No./Substance:
4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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