Document Detail


Evaluation of anticoagulants in patients with cerebral infarction with slight to moderate neurological deficit.
MedLine Citation:
PMID:  6356767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a non-randomized controlled study carried out on 238 hospitalized patients with cerebral infarction, anticoagulant treatment (AC) was compared with the natural course in the prevention of transient ischemic attacks (TIA), cerebral infarction, stroke, stroke or death. 137 patients were allocated to AC, mean follow-up 30.5 months, and 101 patients were allocated to the controls (untreated group), mean follow-up 25.2 months. There were no statistically significant differences among the patients in the group who had suffered TIA (AC treated group 10.2%, untreated group 5.9%), cerebral infarction (AC treated group 10.2%, untreated group 11.9%), stroke (AC treated group 14.6%, untreated group 12.9%), stroke or death (AC treated group 22.6%, untreated group 19.8%). Minor bleedings occurred significantly more frequently (P less than 0.01) in the treated group. Severe bleedings occurred in 8 patients in the treated group (5.8%) compared to 1 of the controls (1%). It is concluded from the trial that AC can only seldom be recommended as prophylactic against new strokes in patients with cerebral infarction due to arterial thromboembolism.
Authors:
S E Eriksson; H Link
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  68     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  96-106     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Ischemia / prevention & control*
Cerebral Hemorrhage / chemically induced
Cerebral Infarction / drug therapy*,  prevention & control
Clinical Trials as Topic
Drug Therapy, Combination
Female
Heparin / administration & dosage*,  adverse effects
Humans
Male
Middle Aged
Warfarin / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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