Document Detail

Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion.
MedLine Citation:
PMID:  16129928     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antiphospholipid syndrome (APS) is a major reproductive complication in women, which is characterized by recurrent fetal loss, thrombosis, and thrombocytopenia in association with anticardiolipin antibodies (aCL). AIMS: To analyze the prevalence of aCL and antiphosphatidylserine antibodies (aPS) in relation to pregnancy failures in women with the history of recurrent spontaneous abortion. SETTINGS AND DESIGN: A sequential study of 155 patients, who had three or more recurrent spontaneous abortions, was carried out. METHODS AND MATERIALS: Women with unexplained recurrent pregnancy loss in first trimester were selected for this study. Anticardiolipin antibodies IgG and aPS IgG were detected in the serum by the enzyme linked immunosorbent assay method. STATISTICAL ANALYSIS: Percentage calculation was carried out. Two-tailed t-test was performed to know the significance of aCL and aPS total population. RESULT: The levels of aCL IgG and aPS IgG were detected as 40% (62) and 19% (18), respectively in women with history of recurrent abortion. CONCLUSION: Anticardiolipin antibody is found to be the most important factor for recurrent abortion. In addition, women with negative aCL are having positive for another antiphospholipid antibodies like aPS, which may involve in recurrent abortion.
S Velayuthaprabhu; G Archunan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  59     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Department of Animal Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
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MeSH Terms
Abortion, Habitual / immunology*
Antibodies, Anticardiolipin / analysis*
Antibodies, Antiphospholipid / analysis*
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G / analysis
Phosphatidylserines / immunology*
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Immunoglobulin G; 0/Phosphatidylserines

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