Document Detail

Evaluation of antiarrhythmic activity of prostaglandin F2 alpha in man.
MedLine Citation:
PMID:  6353427     Owner:  NLM     Status:  MEDLINE    
Since prostaglandin (PG) F2 alpha had been shown to act anti-arrhythmically in various animal models and also in preliminary investigations in man, further evaluation of this effect was made in 30 patients with cardiac extrasystoles and in 2 patients with tachycardias. PGF2 alpha was infused intravenously at individually adapted consecutive rates from 5 to 100 micrograms/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease of 41% (P less than 0.001) was obtained. One patient showed repeated short interruptions of a ventricular tachycardia. A dose-dependent significant rise in blood pressure and no significant influences on heart rate, PQ interval and QRS interval of the ECG were found. It is concluded that PGF2 alpha has probably no practical importance for the therapy of cardiac arrhythmias.
W Sziegoleit; H Hofmann; R Lange; D Mann; R Pundrich; K Machill; G Hafemeister; W Förster
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  11     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  457-69     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / drug therapy*
Blood Pressure / drug effects
Clinical Trials as Topic
Dose-Response Relationship, Drug
Heart Rate / drug effects
Middle Aged
Prostaglandins F / adverse effects,  therapeutic use*
Tachycardia / drug therapy
Reg. No./Substance:
0/Prostaglandins F; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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