Document Detail


Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Léveille.
MedLine Citation:
PMID:  23870914     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Dendropanax morbifera Léveille, an endemic species in Korea, is best known as a tree that produces a resinous sap. Although D. morbifera is used in folk medicine, its biological activities are poorly understood. In this study, the methanolic extracts of D. morbifera branches, debarked stems, bark, and two different stages of leaves were evaluated for anti-oxidant activity and anti-cancer potential. The debarked stem extract exhibited strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and reducing power compared with other samples. In addition, the cytotoxic activities of these extracts were investigated in human tumour cell lines. The results suggested that the extracts of debarked stems, green leaves, and yellow leaves were the potent source of anti-cancer compounds, particularly in Huh-7 cells. Furthermore, treatment with the extracts of debarked stems, green leaves, and yellow leaves caused an increase of apoptotic or senescent cells in Huh-7 cells. Twenty-four hour treatment with debarked stems extract resulted in the strong induction of p53 and p16, whereas both leaf extracts inhibited the activation of ERK. The debarked stems and green leaf extracts reduced Akt levels in Huh-7 cells, indicating that D. morbifera extracts caused the activation of p16 and p53 pathways. This, together with the inhibition of Akt or ERK signalling, resulted in suppression of Huh-7 cell proliferation. These results suggest that methanolic leaf and debarked stems extracts are a source of anti-oxidant and anti-cancer compounds, and could be developed as a botanical drug.
Authors:
Tae Kyung Hyun; Myeong-Ok Kim; Hyunkyoung Lee; Younjoo Kim; Euikyung Kim; Ju-Sung Kim
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Publication Detail:
Type:  Journal Article     Date:  2013-05-18
Journal Detail:
Title:  Food chemistry     Volume:  141     ISSN:  0308-8146     ISO Abbreviation:  Food Chem     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-07-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702639     Medline TA:  Food Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1947-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry, Gyeongsang National University, Jinju 660-701, Republic of Korea.
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