| Evaluation of anti-inflammatory potential of Chloranthus erectus (Buch.-Ham.) Verd. leaf extract in rats. | |
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MedLine Citation:
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PMID: 19703538 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM OF THE STUDY: Chloranthus erectus (Buch.-Ham.) Verdcourt (Chloranthaceae) is a shrub native to tropical and temperate zone of Eastern Himalaya of India and South-East Asia and have traditionally been used as a folklore medicine to treat localised swelling, joint pain, skin inflammation, fever and bodyache. In this study, an attempt has been made to demonstrate the anti-inflammatory activity of methanol extract obtained from Chloranthus erectus leaves (MECEL) in acute, sub-acute and chronic mouse models. MATERIALS AND METHODS: Inflammation in the hind paw of Wistar albino rat was induced by carrageenan, histamine and serotonin, and tissue granuloma pouch was induced by cotton pellet method. Anti-inflammatory drug-phenylbutazone was used as standard drug for comparison. RESULTS: In acute carrageenan-induced rat hind paw edema, oral administration of MECEL at 200 mg/kg produced significant inhibition of edema by 38.34% (p < 0.01) while the histamine- and serotonin-induced sub-acute model, the inhibition of paw edema reached 52.54% (p < 0.001) and 25.5% (p < 0.01), respectively. In a 7-day study, MECEL at 20 and 50 mg/kg produced significant suppression of cotton pellet-induced tissue granuloma formation in rats. CONCLUSIONS: This preliminary study revealed that the methanol extract of Chloranthus erectus exhibited significant anti-inflammatory activity in the tested models, and may provide the scientific rationale for its popular folk medicine as anti-inflammatory agent. |
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Authors:
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Hui Tag; Nima D Namsa; A K Das; P Kalita; S C Mandal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-22 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 126 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 371-4 Citation Subset: IM |
Affiliation:
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Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi University, Rono Hills, Itanagar 791112, Arunachal Pradesh, India. huitag2008rgu@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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