| Evaluation of angiotensin II receptor blockers for 24-hour blood pressure control: meta-analysis of a clinical database. | |
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MedLine Citation:
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PMID: 12556655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II receptor blockers are well tolerated and improve compliance in hypertensive patients. The need for 24-hour blood pressure control has focused attention on whether all agents in this class maintain smooth antihypertensive effects over a 24-hour period. Insight into this issue emerged from a meta-analysis of five large, multicenter trials in which ambulatory blood pressure monitoring was used to compare the antihypertensive effects of three angiotensin II receptor blockers: telmisartan, losartan, and valsartan. These trials used either a double-blind, placebo-controlled or a prospective, randomized, open-label, blinded-end point design. Initial analysis established the validity of combining ambulatory blood pressure monitoring data from the double-blind, placebo-controlled and prospective, randomized, open-label, blinded-end point designs. Subsequent analyses revealed that telmisartan 80 mg was significantly more effective than losartan 50 mg and valsartan 80 mg for reducing 24-hour mean blood pressure. Furthermore, telmisartan 80 mg was comparable to amlodipine 5 mg for controlling the early morning surge in blood pressure. |
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Authors:
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Joel Neutel; David H G Smith |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 5 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-01-30 Completed Date: 2003-05-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 58-63 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Le Jacq Communications, Inc. |
Affiliation:
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Division of Clinical Pharmacology and Hypertension, Veterans Affairs Medical Center, Long Beach, CA, USA. jmneutel@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Benzimidazoles / therapeutic use Benzoates / therapeutic use Blood Pressure Monitoring, Ambulatory Double-Blind Method Humans Hypertension / drug therapy* Losartan / therapeutic use Multicenter Studies as Topic Prospective Studies Randomized Controlled Trials as Topic Tetrazoles / therapeutic use Valine / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; 0/Tetrazoles; 114798-26-4/Losartan; 137862-53-4/valsartan; 144701-48-4/telmisartan; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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