Document Detail

Evaluation of amylose used as a drug delivery carrier.
MedLine Citation:
PMID:  20231017     Owner:  NLM     Status:  MEDLINE    
The enzyme-dependent conjugates of indomethacin and amylose (Am-IND) were synthesized at room temperature using N,N'-dicyclohexylcarbodiimide (DCC) as a coupling agent and 4-(N,N'-dimethylamino) pyridine (DMAP) as a catalyst. Their structures were characterized by FTIR and (1)H NMR analyses, and the results indicated that the IND residues were conjugated with amylose backbones through ester bonds. For the conjugate with a lower IND content, the better water absorption property was advantageous for enzymes diffusing into the swollen conjugate, resulting in biodegradation of the conjugates and release of IND. In vitro biodegradation evaluation indicated that the Am-IND conjugates were biodegraded in the simulated media of the intestines. In vitro drug release experiments showed that the Am-IND conjugates exhibited a sustained release behavior in the simulated media of the intestines, while IND was hardly released in the simulated gastric fluid. These features provide a great opportunity to use the conjugates as a prodrug for intestinally targeted and controlled release of IND through oral administration. This study may lead to the development of effective methods for utilizing amylose as a new drug delivery carrier.
Xiang Cai; Liqun Yang; Li-Ming Zhang; Qing Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-17
Journal Detail:
Title:  Carbohydrate research     Volume:  345     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  922-8     Citation Subset:  IM    
Institute of Polymer Science, School of Chemistry and Chemical Engineering, BME Center, State Key Laboratory of Optoelectronic Materials and Technologies, DSAPM Lab and PCFM Lab, Sun Yat-Sen University, Guangzhou 510275, China.
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MeSH Terms
Amylose / chemistry*
Dicyclohexylcarbodiimide / chemistry
Drug Carriers / chemistry*,  metabolism*
Esters / chemistry
Gastrointestinal Tract / metabolism
Indomethacin / chemistry
Pyridines / chemistry
Solanum tuberosum / enzymology
Water / chemistry
Reg. No./Substance:
0/4-(dimethylamine)pyridine; 0/Drug Carriers; 0/Esters; 0/Pyridines; 53-86-1/Indomethacin; 538-75-0/Dicyclohexylcarbodiimide; 7732-18-5/Water; 9005-82-7/Amylose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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