Document Detail

Evaluation of alveolar clearance by Tc-99m DTPA radioaerosol inhalation scintigraphy in welders.
MedLine Citation:
PMID:  17134016     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The welding process produces metal fumes and gases which may affect respiratory health. Technetium-99m diethylenetriaminepentaacetic acid (Tc-99m DTPA) dynamic lung scanning is an easy, noninvasive method to assess disorders of alveolar-capillary barrier permeability secondary to epithelial damage. We aimed to investigate the alveolar clearance by Tc-99m DTPA radioaerosol inhalation scintigraphy in welders, to assess additive effects of exposure to welding fumes and cigarette smoking on clearance rate of alveolar epithelium and to determine the correlation between Tc-99m DTPA aerosol lung scintigraphy and spirometric measurements. METHODS: Nine nonsmoking welders, 9 smoking welders, and a control group of 6 nonsmokers and 6 smokers were accepted to the study. Tc-99m DTPA radioaerosol inhalation scintigraphy was performed in all subjects. Clearance half time (Tl/2) was calculated by placing a monoexponential fit on the curves. Penetration index (PI) was also calculated on the first minute image. Pulmonary function tests of welders and control group were compared. RESULTS: The mean T1/2 values of Tc-99m DTPA of the nonsmoking welders were significantly higher than those of the nonsmoking control group (82.1+/-24.3 min and 48.1+/-9.7 min, respectively; p = 0.003). The mean T1/2 values of Tc-99m DTPA of the smoking welders were higher than those of the smoking control group (53.3+/-24.5 min and 44.5+/-9.7 min, respectively; p = 0.510). PI of the nonsmoking welders was significantly higher than that of the nonsmoking control group (0.46+/-0.38 and 0.39+/-0.46 respectively; p = 0.004). PI of the smoking welders was significantly higher than that of smoking control group (0.43+/-0.38 and 0.37+/-0.45, respectively; p = 0.019). There was a negative correlation between T1/2 value and FEV1% (r = -0.468, p = 0.016), FVC% (r = -0.442, p = 0.024) and FEF25-75% (r = -0.391, p = 0.048) in the welders and control group. No statistically significant differences were found in the values of the standard pulmonary function tests of any of the subjects. CONCLUSIONS: Welding seems to decrease alveolar clearance which causes an increase in the penetration index. This was considered to be due to fibrotic changes and increased number of alveolar macrophages induced by welding fumes.
Eser Kaya; Fatma Fidan; Mehmet Unlü; Murat Sezer; Levent Tetik; Murat Acar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  20     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-30     Completed Date:  2007-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  503-10     Citation Subset:  IM    
Department of Nuclear Medicine, Afyon Kocatepe University Medical Faculty, Afyonkarahisar, Turkey.
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MeSH Terms
Lung / pathology
Macrophages / metabolism
Occupational Exposure
Pulmonary Alveoli / metabolism*
Radionuclide Imaging / methods*
Radiopharmaceuticals / pharmacology*
Respiratory Function Tests
Technetium Tc 99m Pentetate / pharmacology*
Time Factors
Tomography, X-Ray Computed / methods
Reg. No./Substance:
0/Radiopharmaceuticals; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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