Document Detail

Evaluation of alveolar amplitude response technique for determination of lung perfusion in exercise.
MedLine Citation:
PMID:  7228757     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of tracer gas venous return on the determination of pulmonary perfusion (Qp) using the alveolar amplitude response technique (AART) to evaluate the applicability of this technique at rest and during exercise. The venous return influence was calculated by a computer simulation applied to a simplified body compartment model. Using the AART method, which neglects the influence of venous return, a simulation based on acetylene as a tracer gas predicted an overestimation of the actual value of Qp ranging from 0 to 10% for all work loads investigated. These theoretical results were compared with experimental results. Experiments with human subjects with acetylene as the tracer gas yielded an underestimation of Qp of about 20% at rest and an overestimation of about 7% under different exercise conditions. Experiments with anesthetized dogs showed an underestimation of Qp of about 12% for acetylene and about 6% for halothane. The theoretical and experimental results related to exercise conditions are thus in good quantitative agreement. The experimental data obtained for acetylene with human subjects at rest and with anesthetized dogs are also in good quantitative agreement. However, they deviate considerably from theoretical predictions. This discrepancy may be due to the simplified body compartment model used in the calculations, which can considerably influence the calculated results, especially for conditions at rest. The main conclusion of this paper is that recirculating tracer gas does not unduly influence results for Qp obtained with the AART method when halothane is used as the tracer gas.
S C Luijendijk; A Zwart; A M van der Kooij; W R de Vries
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  50     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1071-8     Citation Subset:  IM; S    
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MeSH Terms
Blood Volume
Physical Exertion*
Pulmonary Alveoli / radionuclide imaging*
Ventilation-Perfusion Ratio*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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