Document Detail


Evaluation of aldosterone antagonists in healthy man.
MedLine Citation:
PMID:  7045549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of methods to allow the quantitative comparison of aldosterone antagonists in healthy men is reviewed. Pharmacological action is measured against a background of mineralocorticoid excess, induced either by administration of exogenous mineralocorticoid (usually aldosterone or fludrocortisone), or by stimulation of endogenous mineralocorticoid using salt restriction, diuretic administration, or a combination of the two. Use of fludrocortisone as the exogenous mineralocorticoid has proved convenient and useful, but the influence of aldosterone antagonists on potassium metabolism has proved somewhat inconstant in this experimental model. Repeated administration of a medium-potency diuretic appears to provide a clinically relevant situation in which the effect of aldosterone antagonists on potassium metabolism can be assessed. We describe these experimental methods in detail, discuss their applications, and make some suggestions for further research.
Authors:
G T McInnes; J R Shelton; L E Ramsay
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Review    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  4     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1982  
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  49-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / analysis*,  pharmacology
Animals
Diuretics / pharmacology
Dogs
Drug Evaluation
Drug Evaluation, Preclinical
Fludrocortisone / pharmacology
Humans
Male
Mineralocorticoid Receptor Antagonists
Potassium / urine
Rats
Sodium / urine
Spironolactone / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Diuretics; 0/Mineralocorticoid Receptor Antagonists; 127-31-1/Fludrocortisone; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; T2D4XUS623/prorenoate potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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