Document Detail


Evaluation of adverse reactions of aponidine hydrochloride ophthalmic solution.
MedLine Citation:
PMID:  8590259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We prospectively evaluated the adverse reactions of apraclonidine in 20 normal volunteers by instilling a single drop of 1% apraclonidine in their right eyes. Examinations, including blood pressure, pulse rate, conjunctiva and cornea, intraocular pressure (IOP), pupil diameter, basal tear secretion and margin reflex distance of both upper and lower eyelids, were performed prior to entry and at 1, 3, 5 and 7 hours after instillation. The ocular hypotensive effects were statistically significant for apraclonidine-treated eyes throughout the study and also statistically significant for contralateral eyes from three hours after topical administration of 1% apraclonidine. Decreases in systolic blood pressure were statistically, but not clinically, significant. No significant changes in diastolic blood pressure, pulse rate and basal tear secretion were noted. Conjunctival blanching and mydriasis were commonly found. Upper lid retraction was frequently noted. While the elevations of the upper lid margin in most subjects were not more than 2 mm and did not cause noticeable change in appearance, one subject suffered from mechanical entropion and marked corneal abrasion 3 hours after instillation of the medication. This may well be a particularly notable finding in Asian people.
Authors:
S L Lin; S S Liang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  11     ISSN:  1080-7683     ISO Abbreviation:  J Ocul Pharmacol Ther     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-25     Completed Date:  1996-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-78     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Cathay General Hospital, Taipei, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / administration & dosage,  adverse effects*
Adult
Blinking / drug effects
Blood Pressure / drug effects
Clonidine / administration & dosage,  adverse effects,  analogs & derivatives*
Conjunctiva / drug effects
Cornea / drug effects
Drug Evaluation
Female
Heart Rate / drug effects
Humans
Intraocular Pressure / drug effects
Male
Ocular Hypotension / chemically induced
Ophthalmic Solutions
Prospective Studies
Pupil / drug effects
Tears / secretion
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Ophthalmic Solutions; 4205-90-7/Clonidine; 66711-21-5/apraclonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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