| Evaluation of adrenomedullin and endothelin-1: are they factors in the adaptation of maternal vascular system in normotensive pregnancy. | |
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MedLine Citation:
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PMID: 18463805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of our study was to analyse the role of adrenomedullin (AM) and endothelin-1 (ET-1) in the adaptation of the maternal vascular system in normotensive pregnancy. METHODS: Twenty-eight pregnant women, who were normotensive throughout the duration of their pregnancy, were recruited into the study. Plasma levels of AM and ET-1 at each trimester were measured and the AM/ET-1 ratio was calculated. RESULTS: Our experiment showed a significant decrease in plasma concentrations of AM in the first trimester for the study group (n=28) compared with the non-pregnant control group (n=16). There was also a significant decrease in plasma concentrations of ET-1 in all three trimesters (P<0.05) and a significant increase in the AM/ET-1 ratio in all three trimesters (P<0.05) for the study group compared with the control group. CONCLUSION: An alteration in vascular equilibrium between AM and ET-1, favouring AM, may be a reason why the physiological adaptation of the maternal vascular system to pregnancy occurs during normotensive pregnancy. |
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Authors:
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Merih Bayram; Suhha Bostanci; Osman Caglayan; Mustafa N Ilhan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in therapy Volume: 25 ISSN: 0741-238X ISO Abbreviation: Adv Ther Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611864 Medline TA: Adv Ther Country: United States |
Other Details:
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Languages: eng Pagination: 367-74 Citation Subset: T |
Affiliation:
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Department of Obstetrics and Gynaecology, Faculty of Medicine, Gazi University, Bilkent-3 C: 4 No: 7, Bilkent, Ankara, 06800, Turkey. merbay@ttnet.net.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Adrenomedullin / blood* Adult Blood Pressure Cardiovascular Physiological Phenomena* Endothelin-1 / blood* Female Humans Pregnancy / physiology* Pregnancy Trimesters Radioimmunoassay Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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