Document Detail

Evaluation of adrenomedullin and endothelin-1: are they factors in the adaptation of maternal vascular system in normotensive pregnancy.
MedLine Citation:
PMID:  18463805     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of our study was to analyse the role of adrenomedullin (AM) and endothelin-1 (ET-1) in the adaptation of the maternal vascular system in normotensive pregnancy. METHODS: Twenty-eight pregnant women, who were normotensive throughout the duration of their pregnancy, were recruited into the study. Plasma levels of AM and ET-1 at each trimester were measured and the AM/ET-1 ratio was calculated. RESULTS: Our experiment showed a significant decrease in plasma concentrations of AM in the first trimester for the study group (n=28) compared with the non-pregnant control group (n=16). There was also a significant decrease in plasma concentrations of ET-1 in all three trimesters (P<0.05) and a significant increase in the AM/ET-1 ratio in all three trimesters (P<0.05) for the study group compared with the control group. CONCLUSION: An alteration in vascular equilibrium between AM and ET-1, favouring AM, may be a reason why the physiological adaptation of the maternal vascular system to pregnancy occurs during normotensive pregnancy.
Merih Bayram; Suhha Bostanci; Osman Caglayan; Mustafa N Ilhan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in therapy     Volume:  25     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  T    
Department of Obstetrics and Gynaecology, Faculty of Medicine, Gazi University, Bilkent-3 C: 4 No: 7, Bilkent, Ankara, 06800, Turkey.
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MeSH Terms
Adaptation, Physiological*
Adrenomedullin / blood*
Blood Pressure
Cardiovascular Physiological Phenomena*
Endothelin-1 / blood*
Pregnancy / physiology*
Pregnancy Trimesters
Young Adult
Reg. No./Substance:
0/Endothelin-1; 148498-78-6/Adrenomedullin

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