Document Detail


Evaluation of activity and phenotype of alpha1-antitrypsin in a civil population with respiratory complications following exposure to sulfur mustard 20 years ago.
MedLine Citation:
PMID:  19788402     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: The reduced alpha1-antitrypsin (AAT) activities of some phenotypes have been suggested as contributing to the development of respiratory diseases. MATERIALS AND METHODS: One hundred patients with respiratory disease following exposure to sulfur mustard were divided into two groups of 50 based on their respiratory symptoms and compared with a healthy control group. AAT phenotypes were determined in the plasma of all patient and control subjects by isoelectric focusing (IEF). RESULTS: Mean AAT activities in patient and control groups were 3.4 +/- 0.3 and 4.2 +/- 0.1 micromol min(-1) ml(-1), respectively (p < 0.001). No phenotypic alterations were detected. CONCLUSIONS: The difference in the clinical pulmonary symptoms of the two groups was attributed to reduced AAT activity, but this was not manifested as phenotypic changes identifiable by IEF.
Authors:
Majid Shohrati; Navvab Shamspour; Fatemeh Babaei; Ali Amini Harandi; Afshin Mohsenifar; Jafar Aslani; Mostafa Ghanei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Affiliation:
Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Chemical Warfare Agents
Female
Humans
Iran
Isoelectric Focusing
Male
Middle Aged
Mustard Gas / toxicity*
Phenotype
Respiration Disorders / chemically induced,  epidemiology,  etiology*
alpha 1-Antitrypsin / blood*
alpha 1-Antitrypsin Deficiency / complications*
Chemical
Reg. No./Substance:
0/Chemical Warfare Agents; 0/alpha 1-Antitrypsin; 505-60-2/Mustard Gas

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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