| Evaluation of the actions and use of alphaxolone/alphadolone (CT1341) in sheep. | |
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MedLine Citation:
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PMID: 7244375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CT1341 (alphaxolone/alphadolone) (Saffan; Glaxo) at various dose rates was investigated for use as an intravenous anaesthetic agent in sheep and it was found that at least 1.65 mg/kg was required to induce anaesthesia. In an experimental group of animals the effect of CT1341 2.2 mg/kg, on PaO2, PaCO2, paH and mean arterial blood pressure was measured. The drug caused a mild respiratory acidosis accompanied by a slight decrease in PaCO2 tensions. Mean arterial blood pressure decreased by 50 per cent, 30 seconds after injection but this fall lasted for only 10 minutes. Prior administration of either atropine sulphate or mepyramine maleate failed to modify this hypotensive effect. Injection of the vehicle, Cremophor EL, alone had no effect on mean arterial blood pressure. Intracerebroventricular administration of CT1341 while producing anaesthesia failed to produce any hypotension. The drug was used for the induction of anaesthesia in 19 sheep. A mean dose of 3.0 mg/kg was found to be most useful clinically. In a further three sheep an infusion of a dilute solution (0.234 mg/kg per minute) was used to maintain anaesthesia. The most notable clinical feature in sheep was the fast, complete recovery. It is concluded that this agent is an extremely useful drug for the induction and maintenance of anaesthesia in sheep. |
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Authors:
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A E Waterman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Research in veterinary science Volume: 30 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Intravenous
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veterinary Anesthetics* Animals Pregnanediones* / administration & dosage Sheep / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Pregnanediones; 14107-37-0/alphadolone; 23930-19-0/alphaxalone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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