Document Detail

Evaluation of the accuracy of intra-operative gross examination for the surgical management of endometrial cancer.
MedLine Citation:
PMID:  18845374     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to explore the clinical value of intra-operative gross examination for the surgical management of endometrial carcinoma. STUDY DESIGN: A retrospective study was conducted in 424 women who underwent surgical treatment for endometrial carcinoma between January 2002 and December 2006. The results of myometrial invasion and cervical infiltration as assessed by intra-operative gross examination were compared with the final microscopic histopathological results in 401 patients. The accuracy, sensitivity, and specificity were calculated. Chi-squared or Fisher's exact tests were used for the comparison of categorical variables. RESULTS: Intra-operative gross examination correctly identified the depth of microscopic myometrial invasion in 90.3% of patients. The sensitivity in detecting myometrial invasion was 80.6% and the specificity was 92.4%. With regard to cervical involvement, gross examination had an overall accuracy of 84.3%. The sensitivity in detecting cervical involvement was 32.6% and the specificity was 99.0%. Usually, cervical involvement cannot be correctly identified by intra-operative gross examination in patients with diffuse foci. CONCLUSION: The data suggest that intra-operative gross examination is a simple and good method of predicting myometrial invasion, but it may not be the ideal way to assess cervical involvement in endometrial carcinoma.
Yuyan Mao; Xiaoyun Wan; Yaxia Chen; Weiguo Lv; Xing Xie
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Publication Detail:
Type:  Journal Article     Date:  2008-10-09
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  141     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, People's Republic of China.
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MeSH Terms
Cervix Uteri / pathology*
Endometrial Neoplasms / pathology*
False Negative Reactions
Intraoperative Period*
Middle Aged
Myometrium / pathology*
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Uterine Cervical Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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