Document Detail

Evaluation of abnormal heart-rate recovery after exercise testing in patients with diabetes mellitus: correlation with myocardial SPECT and chronotropic parameters.
MedLine Citation:
PMID:  17264774     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Diabetes is associated with abnormal function of the autonomic nervous system, while autonomic dysfunction is related to attenuated heart-rate recovery (HRR) after exercise testing. The purpose of this study was to test whether HRR could be a useful index of myocardial ischaemia in patients suffering from diabetes mellitus. METHODS: We included 206 consecutive patients in this study and excluded patients whose HRR value or the myocardial perfusion imaging could have been influenced by factors other than myocardial ischaemia. The value of HRR was defined as the decrease in the heart rate from peak exercise to 1 min after the termination of the exercise. All patients underwent SPECT myocardial perfusion imaging, combined with exercise testing and we calculated the summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) indexes. RESULTS: Sixty patients had abnormal HRR value. A significant correlation was found between HRR 1 min after exercise and SSS (r=-0.64, P<0.001), SDS (r=0.56, P<0.001) and chronotropic variables. Patients with abnormal HRR value, had a higher frequency of other risk factors (besides diabetes) for CAD, were mostly taking cardioactive medications, had lower efficiency during treadmill testing, and presented more pathologic findings on the scintigram. CONCLUSIONS: Our results suggest that myocardial ischaemia, as it is mainly assessed by myocardial perfusion imaging, has an important correlation with HRR in diabetic patients. HRR value 1 min after exercise may be considered as a useful index of the severity of myocardial ischaemia, in this cohort of patients.
Panagiotis Georgoulias; Nikolaos Demakopoulos; Alexandros Orfanakis; Kostis Xydis; Petros Xaplanteris; Panos Vardas; Ioannis Fezoulidis
Related Documents :
22051584 - Pulmonary rehabilitation in australia: a national survey.
7484894 - Prognostic value of predischarge exercise stress echocardiography after acute myocardia...
22101224 - The exercising together project: design and recruitment for a randomized, controlled tr...
21999294 - A prospective evaluation of non-interval- and interval-based exercise training progress...
3912184 - Beta-adrenoceptor blocking effects and plasma levels of bornaprolol and propranolol in ...
16175494 - Hypothalamic-pituitary-thyroid axis in moderate and intense exercise.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  28     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Department of Nuclear Medicine, University Hospital of Larissa, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cohort Studies
Coronary Circulation / physiology
Diabetes Mellitus / physiopathology*,  radionuclide imaging*
Diabetic Angiopathies / physiopathology,  radionuclide imaging
Exercise / physiology*
Exercise Test
Heart / radionuclide imaging*
Heart Rate / physiology*
Middle Aged
Myocardial Ischemia / physiopathology,  radionuclide imaging
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Radiopharmaceuticals / diagnostic use
Regression Analysis
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gated-SPECT equilibrium radionuclide angiography in right ventricular assessment of patients with re...
Next Document:  Sensitivity of FDG PET, GLUT1 expression and proliferative index in bronchioloalveolar lung cancer.