Document Detail


Evaluation of abdominal fat pad aspiration cytology and grading for detection in systemic amyloidosis.
MedLine Citation:
PMID:  18077977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the diagnostic efficacy of abdominal fat pad aspiration cytology as a screening procedure for systemic amyloidosis and to assess the clinical usefulness of semiquantitative grading criteria of fat pad amyloid deposits. STUDY DESIGN: Aspiration cytology samples from 297 cases of abdominal fat pad were retrospectively analyzed for amyloid deposits. The smears were graded semiquantitatively. The deposits in the smears were compared with histologic evidence of amyloidosis in deeper tissues in 44 cases. RESULTS: Retrospective analysis of 297 cases of aspiration cytology revealed amyloid in 90 cases. Follow-up biopsies from deeper tissues in 44 cases showed presence of systemic amyloidosis in 13 cases. The sensitivity and specificity of abdominal fat pad fine needle aspiration cytology was 78% and 93%, respectively. The positive predictive value was 84% and negative predictive value 90%. CONCLUSION: Fat pad aspiration cytology is a useful screening procedure for diagnosis of systemic amyloidosis. Patients with grade 1 deposits should not undergo a toxic therapeutic regimen on the basis of fat pad cytology alone; histologic confirmation of visceral amyloid deposition in deeper tissue is advised. Patients with grades 2 and 3 deposits may undergo suitable therapy for amyloidosis.
Authors:
Sadhna Dhingra; Narendra Krishnani; Niraj Kumari; Rakesh Pandey
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  51     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  860-4     Citation Subset:  IM    
Affiliation:
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
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MeSH Terms
Descriptor/Qualifier:
Abdomen
Adipose Tissue / chemistry,  metabolism,  pathology*
Adult
Aged
Aged, 80 and over
Amyloid / analysis,  metabolism
Amyloidosis / diagnosis*,  metabolism
Biopsy, Fine-Needle / methods*
Coloring Agents / chemistry
Congo Red / chemistry
Female
Humans
Microscopy, Polarization
Middle Aged
Predictive Value of Tests
Retrospective Studies
Chemical
Reg. No./Substance:
0/Amyloid; 0/Coloring Agents; 573-58-0/Congo Red

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