Document Detail

Evaluation of abdominal fat pad aspiration cytology and grading for detection in systemic amyloidosis.
MedLine Citation:
PMID:  18077977     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the diagnostic efficacy of abdominal fat pad aspiration cytology as a screening procedure for systemic amyloidosis and to assess the clinical usefulness of semiquantitative grading criteria of fat pad amyloid deposits. STUDY DESIGN: Aspiration cytology samples from 297 cases of abdominal fat pad were retrospectively analyzed for amyloid deposits. The smears were graded semiquantitatively. The deposits in the smears were compared with histologic evidence of amyloidosis in deeper tissues in 44 cases. RESULTS: Retrospective analysis of 297 cases of aspiration cytology revealed amyloid in 90 cases. Follow-up biopsies from deeper tissues in 44 cases showed presence of systemic amyloidosis in 13 cases. The sensitivity and specificity of abdominal fat pad fine needle aspiration cytology was 78% and 93%, respectively. The positive predictive value was 84% and negative predictive value 90%. CONCLUSION: Fat pad aspiration cytology is a useful screening procedure for diagnosis of systemic amyloidosis. Patients with grade 1 deposits should not undergo a toxic therapeutic regimen on the basis of fat pad cytology alone; histologic confirmation of visceral amyloid deposition in deeper tissue is advised. Patients with grades 2 and 3 deposits may undergo suitable therapy for amyloidosis.
Sadhna Dhingra; Narendra Krishnani; Niraj Kumari; Rakesh Pandey
Related Documents :
12685787 - Evaluation of sensitivity and specificity of cytologic examination: 269 cases (1999-2000).
9250317 - Use of riu stain in the immediate interpretation of bronchial brushing cytology. compar...
16649227 - Detection of malignant hematopoietic cells in cerebral spinal fluid previously diagnose...
11727147 - Fiberoptic ductoscopy for breast cancer patients with nipple discharge.
3400287 - Transbronchial lung biopsy in diffuse pulmonary disease.
14574007 - Desmoid tumour in familial adenomatous polyposis. a review of literature.
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  51     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  860-4     Citation Subset:  IM    
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipose Tissue / chemistry,  metabolism,  pathology*
Aged, 80 and over
Amyloid / analysis,  metabolism
Amyloidosis / diagnosis*,  metabolism
Biopsy, Fine-Needle / methods*
Coloring Agents / chemistry
Congo Red / chemistry
Microscopy, Polarization
Middle Aged
Predictive Value of Tests
Retrospective Studies
Reg. No./Substance:
0/Amyloid; 0/Coloring Agents; 573-58-0/Congo Red

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cutaneous manifestations in non-Hodgkin's lymphoma.
Next Document:  Evaluation of the FocalPoint GS system performance in an Italian population-based screening of cervi...