Document Detail


Evaluation of Urinary Cotinine Immunoassay Test Strips Used to Assess Smoking Status.
MedLine Citation:
PMID:  21778149     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Validation of smoking status is a vital component for assessing self-reported smoking status. This study examined commercially available urinary cotinine immunoassay strips to evaluate their effectiveness and their reliability in validating self-reported tobacco usage. METHODS: This study compared cotinine values from urinary test strips and liquid chromatography-mass spectrometry (LC-MS/MS) obtained from 100 self-reported nonsmokers and 201 self-reported smokers. RESULTS: The analyzed test strips, with 100 ng/ml as the cutoff value, have 91% (84%-96% CI) specificity and 92% (86%-95% CI) sensitivity. The test strips successfully identified nonsmokers from smokers with excellent reproducibility. However, self-reported smokers have significantly different (p < .001) test strip results when compared with the expected LC-MS/MS values. Conclusions: Overall, the test strip demonstrated that it discriminates nonsmokers from smokers and is an adept alternative to chromatographic methods.
Authors:
Eva Yeh; Geneviève Levasseur; Murray J Kaiserman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  -     ISSN:  1469-994X     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Controlled Substance and Tobacco Directorate, Office of Research and Surveillance, Health Canada, 123 Slater Street 7 floor, Address locator: 3507C, Ottawa, Ontario K1A 0K9, Canada. eva.yeh@hc-sc.gc.ca.
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