| Evaluation of Urinary Biomarkers for the Prognosis of Drug-Associated Chronic Tubulointerstitial Nephritis. | |
| | |
MedLine Citation:
|
PMID: 23147380 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND:: The efficacy of urinary biomarkers for predicting adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described. METHODS:: A total of 54 patients with D-CTIN were prospectively followed-up in this study. The urinary excretion of α1-microglobulin and transforming growth factor-β1 and the activity of urinary N-acetyl-β-D-glucosaminidase (NAG) and matrix metalloproteinases (MMPs) 2 and 9 at baseline were measured. Changes in the estimated glomerular filtration rate (GFR) over a period of 11 to 54 months (median, 38 months) of follow-up were recorded. The efficacy of urinary biomarkers for differentiating patients with various outcomes was tested. Ten patients with IgA nephropathy and 20 healthy volunteers were enrolled as controls. RESULTS:: The areas under the receiver operating characteristic curve for urinary NAG, MMP-9, MMP-2 and α1-microglobulin for predicting deterioration of the estimated GFR were 0.879, 0.867, 0.735 and 0.709, respectively (P < 0.05 for all). Partial regression coefficient results demonstrated that urinary NAG (P = 0.02), MMP-2 (P = 0.046) and MMP-9 (P = 0.041) were inversely correlated with the rate of GFR decline. CONCLUSIONS:: Urinary NAG, MMP-2 and MMP-9 may be considered as possible candidates for forecasting the progression rate of D-CTIN. |
| | |
Authors:
|
Yingjin Shi; Tao Su; Lei Qu; Caili Wang; Xiaomei Li; Li Yang |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Renal Division (YS, TS, LQ, XL, LY), Department of Medicine, First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; and Renal Division (YS, CW), the First Affiliated Hospital of Baotou Medical College, Baotou, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Urothelial Bladder Carcinoma with Choriocarcinomatous Differentiation Presenting with a False-Positi...
Next Document: Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour...