| Evaluation of a Treponema pallidum-specific IgM enzyme immunoassay and Treponema pallidum western blot antibody detection in the diagnosis of maternal and congenital syphilis. | |
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MedLine Citation:
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PMID: 14743076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Congenital syphilis (CS) is a result of untreated or inadequately treated maternal syphilis. CS is more likely with early stages of maternal syphilis, but most mothers lack signs or symptoms and the risk of CS is unclear. GOAL: The goal of this study was to evaluate Treponema pallidum IgM Western blot (TP IgM WB) and a T. pallidum IgM enzyme immunoassay (TP IgM ELISA) in mothers with syphilis to determine if positive tests better indicate a risk of CS than a rapid plasma reagin titer >/=1:16. STUDY DESIGN: Ninety-seven mother-baby pairs with reactive syphilis serology were evaluated. RESULTS: TP IgM WB tests were positive in 18 pregnancies (7 of 18 babies had CS) and negative in 79 pregnancies (7 of 82 babies had CS). Thirty-two mothers had titers >/=1:16 (6 babies with CS) and 65 mothers had titers </=1:8 (8 babies with CS). CONCLUSION: TP IgM tests better identify mothers at risk of delivering babies with CS than maternal titer >/=1:16. |
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Authors:
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Sarah A Rawstron; Swati Mehta; Kenneth Bromberg |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Sexually transmitted diseases Volume: 31 ISSN: 0148-5717 ISO Abbreviation: Sex Transm Dis Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-26 Completed Date: 2004-02-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7705941 Medline TA: Sex Transm Dis Country: United States |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: IM |
Affiliation:
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Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Medical Center of Brooklyn (Kings County Hospital Center and SUNY Downstate), Brooklyn, New York 11203-2098, USA. Sarah.Rawston@downstate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Bacterial / analysis Blotting, Western / methods, standards Enzyme-Linked Immunosorbent Assay / methods, standards Female Humans Immunoglobulin M / immunology Infant, Newborn New York City / epidemiology Predictive Value of Tests Pregnancy Pregnancy Complications, Infectious / blood, diagnosis Prenatal Diagnosis / methods, standards* Sensitivity and Specificity Syphilis / blood, diagnosis Syphilis, Congenital / blood, diagnosis*, epidemiology Treponema pallidum / immunology*, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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