Document Detail

Evaluation of a Treponema pallidum-specific IgM enzyme immunoassay and Treponema pallidum western blot antibody detection in the diagnosis of maternal and congenital syphilis.
MedLine Citation:
PMID:  14743076     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital syphilis (CS) is a result of untreated or inadequately treated maternal syphilis. CS is more likely with early stages of maternal syphilis, but most mothers lack signs or symptoms and the risk of CS is unclear. GOAL: The goal of this study was to evaluate Treponema pallidum IgM Western blot (TP IgM WB) and a T. pallidum IgM enzyme immunoassay (TP IgM ELISA) in mothers with syphilis to determine if positive tests better indicate a risk of CS than a rapid plasma reagin titer >/=1:16. STUDY DESIGN: Ninety-seven mother-baby pairs with reactive syphilis serology were evaluated. RESULTS: TP IgM WB tests were positive in 18 pregnancies (7 of 18 babies had CS) and negative in 79 pregnancies (7 of 82 babies had CS). Thirty-two mothers had titers >/=1:16 (6 babies with CS) and 65 mothers had titers </=1:8 (8 babies with CS). CONCLUSION: TP IgM tests better identify mothers at risk of delivering babies with CS than maternal titer >/=1:16.
Sarah A Rawstron; Swati Mehta; Kenneth Bromberg
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  31     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Medical Center of Brooklyn (Kings County Hospital Center and SUNY Downstate), Brooklyn, New York 11203-2098, USA.
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MeSH Terms
Antibodies, Bacterial / analysis
Blotting, Western / methods,  standards
Enzyme-Linked Immunosorbent Assay / methods,  standards
Immunoglobulin M / immunology
Infant, Newborn
New York City / epidemiology
Predictive Value of Tests
Pregnancy Complications, Infectious / blood,  diagnosis
Prenatal Diagnosis / methods,  standards*
Sensitivity and Specificity
Syphilis / blood,  diagnosis
Syphilis, Congenital / blood,  diagnosis*,  epidemiology
Treponema pallidum / immunology*,  isolation & purification
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin M

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