Document Detail

An evaluation of transmitral and pulmonary venous Doppler indices for assessing murine left ventricular diastolic function.
MedLine Citation:
PMID:  20591622     Owner:  NLM     Status:  MEDLINE    
With the continued development of genetically engineered mouse models of cardiac disease, further advancement of noninvasive techniques for evaluating cardiac diastolic dysfunction in these models would be valuable. Therefore, we performed comprehensive transmitral and pulmonary venous Doppler echocardiographic studies to devise novel indices of diastolic function in a mouse model with cardiac hypertrophy, which were validated against invasively measured hemodynamic parameters. We examined 10 HopX(Tg) transgenic mice with diastolic dysfunction and 10 age-matched controls sedated with 1% to 2% isoflurane (male, age 14-18 weeks). These studies revealed that the acceleration time of the transmitral Doppler E-wave was the best Doppler parameter for unmasking LV diastolic dysfunction in HopX(Tg) mice. This is the first study to assess the utility of the acceleration time of the E-wave and pulmonary venous Doppler echocardiography as a primary diagnostic modality for assessing murine diastolic function.
Lijun Yuan; Tao Wang; Fang Liu; Ethan D Cohen; Vickas V Patel
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2010-06-29
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-12-27     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-97     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Disease Models, Animal*
Echocardiography, Doppler / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Mice, Transgenic
Mitral Valve / ultrasonography*
Pulmonary Veins / ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / ultrasonography*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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