Document Detail

Evaluation of Tc-99m-tetrofosmin single-photon emission computed tomography for detection of chronic exertional compartment syndrome of the leg.
MedLine Citation:
PMID:  16895534     Owner:  NLM     Status:  MEDLINE    
Chronic exertional compartment syndrome (CECS) of the leg is a common, painful condition related to exercise and associated with increased muscle compartment pressure (CP). Invasive methods are currently the method of choice for diagnosing the condition. We investigated the use of Tc-99m-tetrofosmin perfusion single-photon emission computed tomography (SPECT) as a diagnostic tool compared with the gold standard, muscle CP measurement. In 14 subjects perfusion SPECT and CP were measured before and immediately after exercise leading to pain in the lower legs. Six subjects had increased pressures indicating the presence of CECS. In three (50%) of these muscular hypoperfusion was observed by perfusion SPECT. In eight subjects with normal CPs SPECT suggested muscular hypoperfusion. Because of the low diagnostic rates, sensitivity 50% and specificity 63%, Tc-99m-tetrofosmin perfusion SPECT seems not to be a useful method for diagnosing CECS.
P S Oturai; T Lorenzen; J Nørregaard; L Simonsen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  16     ISSN:  0905-7188     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-09     Completed Date:  2006-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  282-6     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine and Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen NV, Denmark.
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MeSH Terms
Chronic Disease
Compartment Syndromes / physiopathology,  radionuclide imaging*
Leg / physiopathology,  radionuclide imaging*
Middle Aged
Muscle, Skeletal / blood supply,  physiopathology,  radionuclide imaging
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Physical Exertion / physiology
Prospective Studies
Radiopharmaceuticals / diagnostic use*
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon*
Transducers, Pressure
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

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