Document Detail

Evaluation of T cell subsets with monoclonal antibodies in synovial fluid in rheumatoid arthritis.
MedLine Citation:
PMID:  6219220     Owner:  NLM     Status:  MEDLINE    
Monoclonal antibodies that react with all T cells (OKT3), the inducer-helper T cell subset (OKT4), and the suppressor-cytotoxic T cell subset (OKT8) have been used to evaluate T cell and T cell subpopulations in synovial fluid (SF) from patients with rheumatoid arthritis (RA). We found that the immunoregulatory ratio of SF lymphocytes ranged from normal values to extremely low values indicating normal to excess numbers of OKT8+ cells. The rheumatoid synovium in patients with RA is characterized by the presence of lymphoid aggregates in which HLA-DR+ interdigitating cells form close contacts with a large number of OKT4+ T cells, while the OKT8+ T cells are sparse. It may be that the localizing mechanisms for OKT8+ suppressor cells in lymphoid aggregates are deficient in RA and the cells are thus permitted to pass into synovial exudates, resulting in an increase of OKT8+ cells in the SF.
E M Veys; P Hermanns; G Verbruggen; J Schindler; G Goldstein
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  9     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / immunology*
Arthritis, Rheumatoid / immunology*
Leukocyte Count
Middle Aged
Synovial Fluid / immunology*
T-Lymphocytes / classification*,  immunology
T-Lymphocytes, Regulatory / immunology
Reg. No./Substance:
0/Antibodies, Monoclonal

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