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Evaluation of status of cadmium, lead, and nickel levels in biological samples of normal and night blindness children of age groups 3-7 and 8-12 years.
MedLine Citation:
PMID:  20703825     Owner:  NLM     Status:  In-Data-Review    
The causes of night blindness in children are multifactorial, and particular consideration has been given to childhood trace metals toxicity, which is the most common problem found in underdeveloped countries. This study was designed to compare the levels of cadmium (Cd), lead (Pb), and nickel (Ni) in scalp hair, blood, and urine of night blindness children age ranged 3-7 and 8-12 years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion procedure was developed as a sample pretreatment, for the determination of Cd, Pb, and Ni in biological samples of night blindness children. The proposed method was validated by using conventional wet digestion and certified reference samples of hair, blood, and urine. The digests of all biological samples were analyzed for Cd, Pb, and Ni by electrothermal atomic absorption spectrometry. The results indicated significantly higher levels of Cd, Pb, and Ni in the biological samples (blood, scalp hair, and urine) of male and female night blindness children, compared with control subjects of both genders. These data present guidance to clinicians and other professional investigating toxicity of trace metals in biological samples of night blindness children.
Hassan Imran Afridi; Tasneem Gul Kazi; Naveed Kazi; Sirajuddin; Ghulam Abbas Kandhro; Jameel Ahmed Baig; Abdul Qadir Shah; Sham Kumar Wadhwa; Sumaira Khan; Nida Fatima Kolachi; Faheem Shah; Mohammad Khan Jamali; Mohammad Balal Arain
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Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  Biological trace element research     Volume:  142     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  350-61     Citation Subset:  IM    
National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan,
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