Document Detail


Evaluation of the stability and antioxidant activity of nanoencapsulated resveratrol during in vitro digestion.
MedLine Citation:
PMID:  22026647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol was encapsulated in oil-in-water food-grade nanoemulsions of subcellular size, produced by high-pressure homogenization. Physicochemical stability was evaluated under accelerated aging (high temperature and UV light exposure), as well as during simulated gastrointestinal digestion. Antioxidant activity was assessed at different stages of digestion by chemical assays and by an improved cellular assay, to measure exclusively the residual activity of resveratrol that penetrated inside Caco-2 cells. Results showed that the nanoemulsions based on soy lecithin/sugar esters and Tween 20/glycerol monooleate were the most physically and chemically stable, in terms of mean droplet size (always <180 nm) and resveratrol loading, during both accelerated aging and gastrointestinal digestion. These formulations also exhibited the highest chemical and cellular antioxidant activities, which was comparable to unencapsulated resveratrol dissolved in DMSO, suggesting that nanoencapsulated resveratrol, not being metabolized in the gastrointestinal tract, can be potentially absorbed through the intestinal wall in active form.
Authors:
Mariarenata Sessa; Rong Tsao; Ronghua Liu; Giovanna Ferrari; Francesco Donsì
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-11
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  59     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  2012-03-13     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12352-60     Citation Subset:  IM    
Affiliation:
Department of Industrial Engineering, University of Salerno, via Ponte don Melillo, 84084 Fisciano (SA), Italy.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants* / chemistry,  pharmacology
Caco-2 Cells
Capsules
Chemistry, Pharmaceutical
Digestion*
Drug Stability
Emulsions
Humans
Nanotechnology
Stilbenes / metabolism*,  pharmacokinetics,  pharmacology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Capsules; 0/Emulsions; 0/Stilbenes; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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