| Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion. | |
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MedLine Citation:
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PMID: 22026647 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Resveratrol was encapsulated in O/W food-grade nanoemulsions of subcellular size, produced by high pressure homogenization. Physicochemical stability was evaluated under accelerated ageing (high temperature and UV light exposure), as well as during simulated gastro-intestinal digestion. Antioxidant activity was assessed at different stages of digestion by chemical assays and by an improved cellular assay, to measure exclusively the residual activity of resveratrol that penetrated inside Caco-2 cells. Results showed that the nanoemulsions based on soy lecithin/sugar esters and Tween 20/glycerol monooleate were the most physically and chemically stable, in terms of mean droplet size (always <180 nm) and resveratrol loading, both during accelerated ageing and gastro-intestinal digestion. These formulations also exhibited the highest chemical and cellular antioxidant activity, which was comparable to unencapsulated resveratrol dissolved in DMSO, suggesting that nanoencapsulated resveratrol, not being metabolized in the gastro-intestinal tract, can be potentially absorbed through the intestinal wall in active form. |
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Authors:
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Mariarenata Sessa; Rong Tsao; Ronghua Liu; Giovanna Ferrari; Francesco Donsì |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-26 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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