Document Detail

Evaluation of Sigmoidal Maturation and Allometric Models: Prediction of Propofol Clearance in Neonates and Infants.
MedLine Citation:
PMID:  22198070     Owner:  NLM     Status:  Publisher    
The main objectives of this report are to predict propofol clearance in neonates and infants by a maturation model that includes age and weight and to compare the predictive performance of propofol maturation model with a simple allometric model (clearance vs. body weight). Age, weight, and propofol clearance data were obtained from the literature. A maturation model for propofol was developed using data from neonates, toddlers, children, adolescents, and adults (N = 71). The allometric model was developed using the same data as the maturation model. The predicted clearance of propofol in an individual neonate or infant from these models was compared with the observed clearance (16 neonates and 22 infants) in that individual neonate or infant. The prediction of propofol clearance in most of the individual neonates or infants by both maturation and allometric models was poor. However, the mean predicted propofol clearance in the neonates by both models was comparable with the observed clearance, but the mean predicted propofol clearance in the infants was underpredicted by both models. The propofol maturation and simple allometric model performed poorly for the prediction of propofol clearance in individual neonate and infant.
Iftekhar Mahmood
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-23
Journal Detail:
Title:  American journal of therapeutics     Volume:  -     ISSN:  1536-3686     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Office of Blood Review & Research, Center for Biologic Evaluation and Research, Food and Drug Administration, Rockville, MD.
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