Document Detail


Evaluation of serum creatinine concentration-based glomerular filtration rate equations in pediatric patients with chronic kidney disease.
MedLine Citation:
PMID:  22623290     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVE: To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney disease.
DESIGN: Retrospective, observational, cross-sectional study.
SETTING: Single-center, academic, outpatient pediatric nephrology clinic.
PATIENTS: Fifty-three pediatric patients with stages 2-5 chronic kidney disease who completed GFR assessment with (125) I-iothalamate between January 2002 and January 2005.
MEASUREMENT AND MAIN RESULTS: Data were collected from each patient's medical record. Glomerular filtration rate data were analyzed using 59 evaluations from the 53 pediatric patients. (125) I-iothalamate clearance was used as the index GFR. The Bedside CKiD and Counahan-Barratt equations outperformed the Schwartz and Leger equations when the index GFR was less than 60 ml/minute/1.73 m(2) ; the Schwartz and Counahan-Barratt equations performed best for index GFRs of 60 ml/minute/1.73 m(2) or greater. Overestimation was highest with the Schwartz and Leger equations (> 20% index GFR in 57.6% and 62.7% of patients, respectively). Underestimation was highest with the Bedside CKiD and Counahan-Barratt equations (> 20% index GFR in 30.5% and 28.8%, respectively).
CONCLUSION: The new Bedside CKiD equation performed well for pediatric patients with moderate-to-severe chronic kidney disease, but less well for pediatric patients with mild disease. Additional studies are needed to develop more precise GFR equations using serum creatinine concentration.
Authors:
Carlton K K Lee; Rita D Swinford; Ruby D Cerda; Ronald J Portman; Wenke Hwang; Susan L Furth
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-05-24
Journal Detail:
Title:  Pharmacotherapy     Volume:  32     ISSN:  1875-9114     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-04     Completed Date:  2012-11-16     Revised Date:  2013-07-25    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  642-8     Citation Subset:  IM    
Copyright Information:
© 2012 Pharmacotherapy Publications, Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287-6180, USA. cleea@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Chronic Disease
Creatinine / blood*
Cross-Sectional Studies
Female
Glomerular Filtration Rate*
Humans
Kidney Diseases / diagnosis*,  physiopathology
Kidney Function Tests / methods
Male
Retrospective Studies
Severity of Illness Index
Young Adult
Grant Support
ID/Acronym/Agency:
K24 DK078737/DK/NIDDK NIH HHS; U01 DK066174/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
60-27-5/Creatinine
Comments/Corrections

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