| Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. | |
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MedLine Citation:
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PMID: 22530711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have shown that Garcinia cambogia plays an important role in the regulation of endogenous lipid biosynthesis. This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA. Although several studies have found that the administration of G. cambogia extracts is associated with body weight and fat loss in both experimental animals and humans, we should be cautious when interpreting the results as other randomized, placebo-controlled clinical trials have not reported the same outcomes. Furthermore, most studies in humans have been conducted on small samples and mainly in the short term. None of them have shown whether these effects persist beyond 12 weeks of intervention. Therefore, there is still little evidence to support the potential effectiveness and long-term benefits of G. cambogia extracts. With regard to toxicity and safety, it is important to note that except in rare cases, studies conducted in experimental animals have not reported increased mortality or significant toxicity. Furthermore, at the doses usually administered, no differences have been reported in terms of side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls. |
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Authors:
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Fabiola Márquez; Nancy Babio; Mònica Bulló; J Salas-Salvadó |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Critical reviews in food science and nutrition Volume: 52 ISSN: 1549-7852 ISO Abbreviation: Crit Rev Food Sci Nutr Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-25 Completed Date: 2012-08-07 Revised Date: 2012-09-21 |
Medline Journal Info:
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Nlm Unique ID: 8914818 Medline TA: Crit Rev Food Sci Nutr Country: England |
Other Details:
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Languages: eng Pagination: 585-94 Citation Subset: IM |
Affiliation:
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Human Nutrition Unit, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Rovira i Virgili University, Reus, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP Citrate (pro-S)-Lyase
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antagonists & inhibitors Animals Anti-Obesity Agents / adverse effects, therapeutic use Citrates / adverse effects, therapeutic use* Dietary Supplements / adverse effects Dyslipidemias / diet therapy, drug therapy Enzyme Inhibitors / adverse effects, therapeutic use Fruit / chemistry* Garcinia cambogia / chemistry* Humans Hypolipidemic Agents / adverse effects, therapeutic use* Overweight / diet therapy, drug therapy Phytotherapy / adverse effects Plant Extracts / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Citrates; 0/Enzyme Inhibitors; 0/Hypolipidemic Agents; 0/Plant Extracts; 6205-14-7/hydroxycitric acid; EC 2.3.3.8/ATP Citrate (pro-S)-Lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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