Document Detail


Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease.
MedLine Citation:
PMID:  15513309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To relate ECG and heart rate (HR) variables during and after exercise testing with the presence of one-, two- or three-vessel disease defined by angiography. DESIGN: Seventy-three male patients with stable angina pectoris and angiographically verified coronary artery disease underwent a maximal exercise test. From 12-lead ECG recordings and computer averaging ST-amplitude and HR data were measured in consecutive 10-s intervals. RESULTS: In univariate analysis, patients with three-vessel disease had lower maximal exercise capacity, a shorter time to >1 mm ST-depression, more often a clockwise ST/HR recovery loop, more frequently a post-exercise downward ST-segment slope, and a greater ST-deficit at 3.5 min after exercise than patients with one-vessel disease. In multivariate analysis, time to >1 mm ST-depression discriminated between patients with three- and one-vessel disease. In patients with an intermediate time to >1 mm ST-depression a clockwise ST/HR recovery loop and/or a downsloping ST-segment in the post-exercise period were significantly more prevalent in severe vessel disease. CONCLUSION: Patients with three-vessel disease had a significantly shorter time to >1 mm ST-depression during exercise and more often an abnormal post-exercise ST/HR reaction than those with one-vessel disease.
Authors:
Thorvald Bjurö; Lars Gullestad; Knut Endresen; Margareta Nordlander; Anders Malm; Lena Höglund; Inger Wahlqvist; John Pernow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  38     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-03-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  270-7     Citation Subset:  IM    
Affiliation:
AstraZeneca R&D, Mölndal, Sweden. thorvald.bjuro@astrazeneca.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / diagnosis
Coronary Angiography
Coronary Artery Disease / classification,  diagnosis*,  physiopathology,  radiography
Electrocardiography*
Exercise Test*
Humans
Male
Middle Aged
Reference Values
Stroke Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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