Document Detail

Evaluation of right ventricle function in children with primary nephrotic syndrome.
MedLine Citation:
PMID:  20675241     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We aimed to evaluate right ventricle (RV) function in children with primary nephrotic syndrome (PNS).
METHODS: RV hemodynamics were evaluated by Doppler echocardiography in 50 children with PNS (aged 2.5-12 years), either at PNS onset (n = 37) or relapse (n = 13), and in 50 normal controls. Heart rate, stroke volume, cardiac output, RV enddiastolic and end-systolic volume, RV ejection fraction, RV end-diastolic pressure, RV peak systolic and end-systolic pressure were determined from pressure-volume loops. The maximal rates of RV pressure upstroke and fall (dP/d t(max) and dP/d t(min), respectively) were calculated. Effective pulmonary arterial elastance was calculated as end-systolic pressure divided by stroke volume. Plasma tumor necrosis factor-alpha (TNF-alpha) and insulin-like growth factor 1 (IGF-1) were also measured.
RESULTS: RV end-diastolic pressure was increased by an average of 20% in 39 of the patients with PNS, whereas RV ejection fraction was reduced by an average of 15% compared with controls (p < 0.05 for both). Cardiac output and stroke volume were maintained, indicating compensation at the expense of increased RV end-diastolic and end-systolic volumes and increased RV filling pressure (p < 0.05). Plasma TNF-alpha was elevated in patients with PNS (326 +/- 117 kU/L vs. 75 +/- 23 kU/L, p < 0.05); IGF-1 was similar in PNS patients and controls.
CONCLUSION: Right ventricle function was impaired in children with PNS. The characteristics were unrelated to blood pressure and IGF-1, but may be correlated with TNF-alpha and disease duration. Further studies are needed to evaluate the etiology and clinical implications of this abnormality.
Qiang Qin; Ruiying Xu; Junhua Dong; Wei Xia; Ruopeng Sun
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  51     ISSN:  1875-9572     ISO Abbreviation:  Pediatr Neonatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-09-16     Revised Date:  2011-01-27    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
Copyright Information:
2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
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MeSH Terms
Biological Markers / blood
Cardiac Output / physiology
Case-Control Studies
Chi-Square Distribution
Child, Preschool
Echocardiography, Doppler
Heart Rate / physiology
Heart Ventricles / ultrasonography
Insulin-Like Growth Factor I / metabolism
Nephrotic Syndrome / physiopathology*
Regression Analysis
Tumor Necrosis Factor-alpha / blood
Vascular Resistance
Ventricular Function, Right / physiology*
Reg. No./Substance:
0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 67763-96-6/Insulin-Like Growth Factor I
Erratum In:
Pediatr Neonatol. 2010 Dec;51(6):367-8

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