| Evaluation of right ventricle function in children with primary nephrotic syndrome. | |
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MedLine Citation:
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PMID: 20675241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We aimed to evaluate right ventricle (RV) function in children with primary nephrotic syndrome (PNS). METHODS: RV hemodynamics were evaluated by Doppler echocardiography in 50 children with PNS (aged 2.5-12 years), either at PNS onset (n = 37) or relapse (n = 13), and in 50 normal controls. Heart rate, stroke volume, cardiac output, RV enddiastolic and end-systolic volume, RV ejection fraction, RV end-diastolic pressure, RV peak systolic and end-systolic pressure were determined from pressure-volume loops. The maximal rates of RV pressure upstroke and fall (dP/d t(max) and dP/d t(min), respectively) were calculated. Effective pulmonary arterial elastance was calculated as end-systolic pressure divided by stroke volume. Plasma tumor necrosis factor-alpha (TNF-alpha) and insulin-like growth factor 1 (IGF-1) were also measured. RESULTS: RV end-diastolic pressure was increased by an average of 20% in 39 of the patients with PNS, whereas RV ejection fraction was reduced by an average of 15% compared with controls (p < 0.05 for both). Cardiac output and stroke volume were maintained, indicating compensation at the expense of increased RV end-diastolic and end-systolic volumes and increased RV filling pressure (p < 0.05). Plasma TNF-alpha was elevated in patients with PNS (326 +/- 117 kU/L vs. 75 +/- 23 kU/L, p < 0.05); IGF-1 was similar in PNS patients and controls. CONCLUSION: Right ventricle function was impaired in children with PNS. The characteristics were unrelated to blood pressure and IGF-1, but may be correlated with TNF-alpha and disease duration. Further studies are needed to evaluate the etiology and clinical implications of this abnormality. |
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Authors:
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Qiang Qin; Ruiying Xu; Junhua Dong; Wei Xia; Ruopeng Sun |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics and neonatology Volume: 51 ISSN: 1875-9572 ISO Abbreviation: Pediatr Neonatol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-09-16 Revised Date: 2011-01-27 |
Medline Journal Info:
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Nlm Unique ID: 101484755 Medline TA: Pediatr Neonatol Country: Singapore |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Copyright Information:
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2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China. qin-qiang@126.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiac Output / physiology Case-Control Studies Chi-Square Distribution Child Child, Preschool Echocardiography, Doppler Electrocardiography Female Heart Rate / physiology Heart Ventricles / ultrasonography Hemodynamics Humans Insulin-Like Growth Factor I / metabolism Male Nephrotic Syndrome / physiopathology* Regression Analysis Tumor Necrosis Factor-alpha / blood Vascular Resistance Ventricular Function, Right / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tumor Necrosis Factor-alpha; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
Erratum In:
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Pediatr Neonatol. 2010 Dec;51(6):367-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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