Document Detail

Evaluation of resynchronization therapy for heart failure in patients with a QRS duration greater than 120 ms (GREATER-EARTH) trial: rationale, design, and baseline characteristics.
MedLine Citation:
PMID:  21791363     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart failure is considered an epidemic of the modern era. In selected candidates on optimal medical therapy, cardiac resynchronization therapy (CRT) has emerged as a valuable adjunctive treatment. Despite its demonstrated salutary effects on clinical evolution, left ventricular (LV) function, and overall survival, at least 30% of patients fail to respond to CRT.
METHODS: The Greater Evaluation of Resychronization Therapy for Heart Failure (GREATER-EARTH) ( Identifier NCT00901212) is a randomized, double-blind, multicentre study involving 11 centres across Canada and compares LV CRT with biventricular CRT in patients with severe LV dysfunction and a QRS duration>120 ms.
RESULTS: This article describes the rationale and design of the study and presents the baseline characteristics of all randomized patients. The primary outcome consists of the effects of CRT on submaximal exercise tolerance (treadmill test), and secondary outcomes explore mechanisms of asynchrony and effects of CRT on asynchrony and LV function.
CONCLUSION: The study was initiated in November 2003, with the last patient randomized on February 12, 2009. As expected, follow-up was in February 2010 and the results are presently being analyzed in March 2010.
Bernard Thibault; François Harel; Anique Ducharme; Michel White; Nancy Frasure-Smith; Denis Roy; François Philippon; Paul Dorian; Mario Talajic; Marc Dubuc; Pierre Gagné; Peter G Guerra; Laurent Macle; Léna Rivard; Paul Khairy
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-07-24
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  27     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-01-19     Revised Date:  2012-03-12    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  779-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Cardiac Resynchronization Therapy / methods*
Cross-Over Studies
Double-Blind Method
Exercise Tolerance / physiology*
Heart Failure / physiopathology,  therapy*
Middle Aged
Research Design
Treatment Outcome
Ventricular Function, Left / physiology*
Grant Support
67914//Canadian Institutes of Health Research

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