Document Detail


Evaluation of the prognostic factors and significance of lymph node status in invasive ductal carcinoma of the body or tail of the pancreas.
MedLine Citation:
PMID:  19910836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We evaluated prognostic indicators for distal pancreatectomy with regional lymph node dissection in pancreatic body or tail carcinoma. METHODS: Between 1993 and 2008, 50 patients with ductal carcinoma of the body or tail of the pancreas who underwent distal pancreatectomy with regional lymph node dissection were retrospectively analyzed. Clinicopathological factors associated with patient survival were evaluated. RESULTS: No in-hospital deaths occurred among the study patients. The overall 5-year survival rate was 19.3%, and median survival was 22.6 months. Univariate analysis revealed that lymph node metastasis, intrapancreatic neural infiltration, peripancreatic nerve plexus infiltration, and tumor differentiation affected patient survival significantly. Multivariate analysis validated lymph node metastasis as an independent prognostic factor. Moreover, the lymph nodes attached to the pancreas were the most frequent metastatic nodes, and the number of metastasis in the lymph nodes attached to the pancreas was significantly associated with survival after surgical resection. CONCLUSIONS: Lymph node metastasis was a significant and independent prognostic factor for the surgically resected pancreatic body or tail carcinoma. Furthermore, the lymph nodes attached to the pancreas were the most frequent metastatic nodes, and these lymph nodes were potential indicators predicting both tumor extension and survival after surgery for pancreatic body or tail carcinoma.
Authors:
Takeo Fujita; Toshio Nakagohri; Naoto Gotohda; Shinichiro Takahashi; Masaru Konishi; Motohiro Kojima; Taira Kinoshita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  39     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48-54     Citation Subset:  IM    
Affiliation:
Division of Digestive Surgery, National Cancer Center Hospital East, Kashiwa, Japan. takfujit@east.ncc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Pancreatic Ductal / pathology*,  surgery
Female
Humans
Kaplan-Meiers Estimate
Lymph Nodes / pathology*
Lymphatic Metastasis
Male
Middle Aged
Multivariate Analysis
Pancreas / pathology,  surgery
Pancreatectomy / statistics & numerical data
Pancreatic Neoplasms / pathology*,  surgery
Prognosis
Proportional Hazards Models
Regression Analysis
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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