| Evaluation of Parotid Gland Function using Equivalent Cross-relaxation Rate Imaging Applied Magnetization Transfer Effect. | |
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MedLine Citation:
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PMID: 22302054 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Safe imaging modalities are needed for evaluating parotid gland function. The aim of this study was to validate the utility of a magnetic resonance imaging (MRI) tool, equivalent cross-relaxation rate imaging (ECRI), as a measurement of parotid gland function after chemoradiotherapy. Subjects comprised 18 patients with head-neck cancer who underwent ECRI and salivary gland scintigraphy. First, we calculated ECR values (signal intensity on ECRI), maximum uptake rate (MUR) and washout rate (WOR) from salivary gland scintigraphy data at the parotid glands. Second, we investigated correlations between ECR values and each parameter of MUR (uptake function) and WOR (secretory function) obtained by salivary gland scintigraphy at the parotid gland. Next, we investigated each dose-response for ECR, MUR and WOR at the parotid gland. A correlation was detected between ECR values and MUR in both the pre- (r = -0.55, p < 0.01) and post-treatment (r = -0.50, p < 0.05) groups. A significant post-treatment correlation was detected between the percentage change in ECR values at 3-5 months after chemoradiotherapy and median dose to the parotid gland (Pearson correlation, r = -0.62, p < 0.05). However, no correlations were detected between median dose to the parotid gland and either MUR or WOR. ECRI is a new imaging tool for evaluating the uptake function of the parotid gland after chemoradiotherapy. |
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Authors:
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Hidetoshi Shimizu; Shigeru Matsushima; Yasutomi Kinosada; Hiroki Miyamura; Natsuo Tomita; Takashi Kubota; Hikaru Osaki; Masashi Nakayama; Manabu Yoshimoto; Takeshi Kodaira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of radiation research Volume: 53 ISSN: 1349-9157 ISO Abbreviation: J. Radiat. Res. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376611 Medline TA: J Radiat Res (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 138-44 Citation Subset: IM |
Affiliation:
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Department of Therapeutic Radiation Oncology, Aichi Cancer Center Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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