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Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls.
MedLine Citation:
PMID:  24082465     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In the present study, oxidative stress and lymphocytic DNA damage in both pre-op and post-op benign prostrate hyperplasia (BPH) patients with age >50 years was evaluated and compared with normal healthy subjects (controls- without any evidence of disease) of the same sex and age group. From December 2007 to November 2009, oxidative stress in 45 BPH patients were evaluated both before (pre-op patients) and after 7 days of surgery (post-op patients) in terms of measurements of plasma levels of (1) various anti-oxidative enzymes, (2) non-enzymatic antioxidants and (3) malondialdehyde which is a product of lipid peroxidation. The lymphocyte DNA damage was also evaluated by single cell alkaline gel electrophoresis in terms of tail length migration in these patients. These values were compared with their respective control subjects of similar sex and age group. The activities of antioxidant enzymes and the levels of antioxidant, reduced glutathione were found significantly decreased (p < 0.05) in serum samples of pre-operative group of BPH patients as compared to the controls. These altered parameters increased significantly (p < 0.05) and returned to their near normal control values, but not up to baseline values, in post operative patients i.e. after the cancer load was decreased by surgery. Lymphocytic DNA damage was found to be significantly increased in pre-op group as compared to controls and was reduced after surgery in post-op group. The present study therefore, shows significantly increased levels of oxidative stress and DNA damage in BPH patients which were reduced after removal of tumour load. Thus oxidative damage plays an important role in prostate tumourogenesis and timely management of oxidative stress can be of importance in preventing the occurrence of BPH.
Authors:
Manzoor Ahmad; Nida Suhail; Tariq Mansoor; Naheed Banu; Shamshad Ahmad
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Publication Detail:
Type:  Journal Article     Date:  2012-06-12
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  27     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-10-01     Completed Date:  2013-10-01     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  -    
Affiliation:
Department of General Surgery, J.N. Medical College, A.M.U., Aligarh, India.
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