Document Detail

An evaluation of methods to improve the reporting of adherence in a placebo gel trial in Andhra Pradesh, India.
MedLine Citation:
PMID:  23299877     Owner:  NLM     Status:  MEDLINE    
Female sex workers (FSWs) were recruited for a 4-month placebo vaginal gel trial in Nellore, India. Two experiments explored if prior knowledge of biomarkers for unprotected sex and insertion of gel applicators would yield more accurate self-reports. A third experiment compared self-reports of gel use and adherence levels between FSWs randomly assigned to interactive voice response survey (IVRS) and those assigned to paper diaries. Prior knowledge of biomarkers did not improve accuracy of self-reported condom or gel use, nor did it affect actual adherence. Of those who tested positive for the presence of semenogelin in the vagina, 76% reported no unprotected sex in the previous 48 h. Overall, women reported using gel on 90% of days whereas the biomarker indicated gel use on fewer than 50% of days. Compliance to IVRS was low, despite familiarity with mobile phone technology. Additional explorations with other populations are needed.
Sharon A Abbott; Barbara A Friedland; Avina Sarna; Lauren L Katzen; Ulrike Rawiel; Aylur K Srikrishnan; C S Shalini; Waimar Tun; Christine A Kelly; Suniti Solomon; Barbara S Mensch
Related Documents :
14620167 - Adverse long-term effect of corticosteroid therapy in recent-onset sarcoidosis.
24245707 - Internet-based exposure treatment versus one-session exposure treatment of snake phobia...
8912267 - Cardiovascular responses to tests for autonomic dysfunction in patients with chronic ob...
24441617 - Work-related musculoskeletal symptoms among construction workers in the pipe trades.
15094257 - Single photon emission computed tomography in posttraumatic stress disorder before and ...
21942787 - Effect of mechanical debridement on distal periodontal aspects of second molars after t...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  AIDS and behavior     Volume:  17     ISSN:  1573-3254     ISO Abbreviation:  AIDS Behav     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-05     Completed Date:  2013-08-30     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9712133     Medline TA:  AIDS Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2222-36     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Intravaginal
Anti-Infective Agents / therapeutic use
Biological Markers / analysis
HIV Infections / prevention & control
Health Knowledge, Attitudes, Practice
Medication Adherence*
Middle Aged
Self Report
Sex Workers
Unsafe Sex / prevention & control,  statistics & numerical data
Vaginal Creams, Foams, and Jellies / therapeutic use*
Young Adult
Grant Support
Reg. No./Substance:
0/Anti-Infective Agents; 0/Biological Markers; 0/Vaginal Creams, Foams, and Jellies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sleep, Function and HIV: A Multi-Method Assessment.
Next Document:  Highly selective azadipeptide nitrile inhibitors for cathepsin K: design, synthesis and activity ass...