Document Detail


An evaluation of methods to improve the reporting of adherence in a placebo gel trial in Andhra Pradesh, India.
MedLine Citation:
PMID:  23299877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Female sex workers (FSWs) were recruited for a 4-month placebo vaginal gel trial in Nellore, India. Two experiments explored if prior knowledge of biomarkers for unprotected sex and insertion of gel applicators would yield more accurate self-reports. A third experiment compared self-reports of gel use and adherence levels between FSWs randomly assigned to interactive voice response survey (IVRS) and those assigned to paper diaries. Prior knowledge of biomarkers did not improve accuracy of self-reported condom or gel use, nor did it affect actual adherence. Of those who tested positive for the presence of semenogelin in the vagina, 76% reported no unprotected sex in the previous 48 h. Overall, women reported using gel on 90% of days whereas the biomarker indicated gel use on fewer than 50% of days. Compliance to IVRS was low, despite familiarity with mobile phone technology. Additional explorations with other populations are needed.
Authors:
Sharon A Abbott; Barbara A Friedland; Avina Sarna; Lauren L Katzen; Ulrike Rawiel; Aylur K Srikrishnan; C S Shalini; Waimar Tun; Christine A Kelly; Suniti Solomon; Barbara S Mensch
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  AIDS and behavior     Volume:  17     ISSN:  1573-3254     ISO Abbreviation:  AIDS Behav     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-05     Completed Date:  2013-08-30     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9712133     Medline TA:  AIDS Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2222-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Adolescent
Adult
Anti-Infective Agents / therapeutic use
Biological Markers / analysis
Female
HIV Infections / prevention & control
Health Knowledge, Attitudes, Practice
Humans
India
Medication Adherence*
Middle Aged
Self Report
Sex Workers
Unsafe Sex / prevention & control,  statistics & numerical data
Vaginal Creams, Foams, and Jellies / therapeutic use*
Young Adult
Grant Support
ID/Acronym/Agency:
R21 HD060270/HD/NICHD NIH HHS; R21-HD060270/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Biological Markers; 0/Vaginal Creams, Foams, and Jellies
Comments/Corrections

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