Document Detail

Evaluation of mechanical allodynia in an animal immobilization model using the von frey method.
MedLine Citation:
PMID:  22054875     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the mechanical allodynia in animals after immobilization and chiropractic manipulation using the Activator instrument (Activator Methods International, Phoenix, Ariz) through the Von Frey test in an animal model that had its hind limb immobilized as a form to induce mechanical allodynia.
METHOD: Eighteen adult male Wistar rats were used and divided into 3 groups: control group (C) (n = 6) that was not immobilized; immobilized group (I) (n = 6) that had its right hind limb immobilized; immobilized and adjusted group (IAA) (n = 6) that had its right hind limb immobilized and received chiropractic manipulation after. The mechanical allodynia was induced through the right hind limb immobilization. At the end of the immobilization period, the first Von Frey test was performed, and after that, 6 chiropractic manipulations on the tibial tubercle were made using the Activator instrument. After the manipulation period, Von Frey test was performed again.
RESULTS: It was observed that after the immobilization period, groups I and IAA had an exacerbation of mechanical allodynia when compared with group C (P < .001) and that after the manipulation, group IAA had a reversion of these values (P < .001), whereas group I kept a low pain threshold when compared with group C (P < .001).
CONCLUSION: This study demonstrates that immobilization during 4 weeks was sufficient to promote mechanical allodynia. Considering the chiropractic manipulation using the Activator instrument, it was observed that group IAA had decreased levels of mechanical allodynia, obtaining similar values to group C.
Jaqueline Trierweiler; Débora Negrini Göttert; Günther Gehlen
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2011-11-04
Journal Detail:
Title:  Journal of manipulative and physiological therapeutics     Volume:  35     ISSN:  1532-6586     ISO Abbreviation:  J Manipulative Physiol Ther     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-13     Completed Date:  2012-05-08     Revised Date:  2013-01-08    
Medline Journal Info:
Nlm Unique ID:  7807107     Medline TA:  J Manipulative Physiol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 National University of Health Sciences. Published by Mosby, Inc. All rights reserved.
Academic of Chiropractic from the University Feevale, Laboratory of Comparative Histophysiology, ICS, University Feevale, Novo Hamburgo, RS, Brazil.
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MeSH Terms
Hyperalgesia / etiology*,  physiopathology,  therapy*
Immobilization / adverse effects*,  methods
Manipulation, Chiropractic / methods*
Models, Animal
Pain Measurement
Pain Threshold / physiology*
Random Allocation
Rats, Wistar
Reference Values
Risk Factors
Comment In:
J Manipulative Physiol Ther. 2012 Oct;35(8):657; author reply 657-8   [PMID:  23158471 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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